CoQ10 supplement, for natural energy and
- -http://healthfully.org/rc/id1.html 3/13/15
You ought to read
summation on the
corporatization of medicine &
practice of medicine. The
pharmaceutical industry (hereafter
referred to as pharma) controls the research, its publication, the continuing
education of doctors, etc. The perception in the press is the opposite of the
truth, a truth which was succinctly stated by Harvard Prof. Marcia Angell: “If
we had set out to design the worst system
that we could imagine, we couldn’t have imagined on as bad as we have.” The lack of awareness by doctors of Q10 is a result
of pharma’s control of information. At under $100/year (Costco), given its benefits, Q10 should be taken life-long.
Coenzyme Q10 exists in 3
redox (reduced/oxidized) states: fully
oxidized (ubiquinone), semiquinone (ubisemiquinone), and fully reduced (ubiquinol). All
3 forms are essentially
bio-equivalent, though ubiquinol
has 10% greater absorption. Coenzyme
Q10 is abbreviated as CoQ10, CoQ, or Q10
is a 1,4-benzoquinone, where “Q” refers to the
group, and 10 refers to the number of isoprenyl
chemical subunits in its tail. It
discovered in 1954, and in the 1980s there was a steep rise in clinical
trials. This oil-soluble, vitamin-like
substance is present in most eukaryotic cells, primarily in the mitochondria,
which is found in every cell in the body [also in LDL, HDL, & the cell
membrane at]. It
is a component of the electron transport chain and participates
in aerobic cellular respiration, generating
energy in the form of ATP. Ninety-five
percent of the human body’s energy is generated
this way. Those organs with the highest energy
requirements—such as the heart, liver, [brain], and kidney—have the highest CoQ10
The capacity of this molecule to exist in a completely oxidized
form and a completely reduced form enables it to perform its functions in the Electron Transport Chain (ETC) and as an antioxidant
respectively. CoQ10 is
fat-soluble and is therefore mobile in cellular membranes; it plays a unique
role in the ETC. In the inner mitochondrial membrane, electrons
from NADH and succinate pass through the ETC
to the oxygen, which is then reduced to water. The transfer of electrons
through ETC results in the pumping
of H+ across the membrane creating a proton gradient across the membrane, which
is used by ATP
synthase (located on the membrane) to generate ATP.
is crucial in the process, since no other molecule can perform this function.
functions in every cell of the body to synthesize energy” (Wik). “Q10
synthesized from farnesyl diphosphate and tyrosine; iron, magnesium and vitamin
B6 are cofactors in synthesis” at.
As an antioxidant, Q10’s also improves
health. “The antioxidant nature
derives from its energy carrier function. As an energy carrier, the CoQ10
molecule is continually going through an oxidation-reduction cycle. As it
accepts electrons, it becomes reduced. As it gives up electrons, it becomes
oxidized. In its reduced form, the CoQ10 molecule holds electrons rather
loosely, so this CoQ10 molecule will quite easily
give up one or both electrons and, thus, act as an antioxidant”(Wiki). It is considered
the best of anti-oxidants because
it is distributed widely in the body and naturally serves this function with a
low energy barrier, and mechanism for recycling. Long-term usage is
required for benefits, especially for
reduction in damage to proteins which cause age related chronic conditions, and
LDL that starts atherogenesis that causes heart disease--summary.
level is in 2-6 hours, and second peak at about 24 hours; half-life is 33
hours. The synthesis
of the precursor of coenzyme Q10, mevalonate, is inhibited by
some beta blockers (blood
pressure-lowering medication), bisphosphonates
antidepressants and other drugs. Q10 does
not interact with drugs or have side effects, and has been shown safe at 2,400 mg & 3,600 mg.
below are also found at total
supplement. Its antioxidant effect prevents the
formation of plaque and thus
atherosclerosis (AS) &
cardiovascular disease (CVD) with
their deadly consequences.
Heart Attack and Angina
pain: Those who
took Q10 supplements starting within 3 days of a heart attack
were less likely to have subsequent heart attacks, less chest pains, die of
heart disease greater capacity for exercise by 30%, also.
Heart failure (HF): People
who have congestive heart failure, their heart isn't able to adequately pump
blood, thus it pools in parts of the body, such as the lungs and legs. “Several
clinical studies suggests that Q10 supplements help reduce
swelling in the legs; reduce fluid in the lungs to making breathing easier; and
increase exercise capacity in people with heart failure, & reduces hospital admissions
by 61%”, similar, also, long-term
and safety. Heart
improves blood sugar level 31% and also lowers high blood pressure in people with
type 2 diabetes. “In conclusion, serum Q10 levels in type 2
diabetes patients are decreased and may be associated with subclinical-diabetic cardiomyopathy reversible by CoQ10 supplementation”.
High blood pressure: In a
meta-analysis of 12
clinical studies, Cochrane
concluded that Q10 lowers systolic
blood pressure by up to
17 mm Hg and diastolic blood pressure by 10 mm Hg at, probably from improved heart
Atherosclerosis, CVD, MI: Q10 is the only antioxidant
to LDL, and thus
slows atherogenesis, and, and.
In the lab Q10 reduced “plaque formation, frequencies of ulceration, thrombosis
or hemorrhage” at.
Sperm, at Wikipedia. “A study
of idiopathic infertile men found after
26 weeks of treatment compared to the placebo cohort significant increase in
sperm volume, motility, improved morphology, and seminal plasma activity.” Also
renal health, and gene expression
controlling inflammation improved, also.
Cancer & chemotherapy: Low levels of Q10 have been
noted with several common cancers, thus it has
been used as a supplement for cancer
victims. Several clinical studies found that Q10 help prevent damage caused by
certain chemotherapy drugs, adriamycin, athracycline. Anti-cancer immune response animal studies.
Heart surgery: Clinical research indicates that”
introducing Q10 prior to heart surgery … can reduce damage caused by free
strengthen heart function, and lower the incidence of irregular heart beat (arrhythmias)….”
Immune system: “Models of the immune system including
phagocytic rate, antibody level, neoplasia, viral and parasitic infections were
used to demonstrate that Q10 is an essential immune-modulating
Gum (Periodontal) disease: topical CoQ10 supplements led to faster healing and tissue
and other neuro-degenerative diseases: slows the progress: “Those who took 1,200 mgs daily had
44% less decline in mental function, motor function.” Q10
also lowers the risk of various other neurodegenerative diseases by reducing neuro-toxic insult, and, and
MS and. Long-term itlowers
the risk Alzheimer’s and vascular dementia, and.
Migraines: Help prevent migraines Thirty-one patients completed the
study; 61.3% of patients had a greater than 50% reduction in number of days
with migraine headache. The average number of days with migraine during the
baseline period was 7.34 and this decreased to 2.95 after 3 months of therapy.
Mean reduction in migraine frequency after 1 month of treatment was 13.1% and
this increased to 55.3% by the end of 3 months.
Degeneration (the leading cause
of blindness in seniors): “Mitochondrial
dysfunctions have been implicated in the pathophysiology of several age-related
diseases including age-related macular degeneration (AMD), a progressive
neurodegenerative disease affecting primarily the retinal pigment epithelium
(RPE). AMD may also develop
in normal aging, 10–15 years after appearing in AMD patients. CoQ10
levels in the retina can decline
by approximately 40% with age.” Moreover
Vitamin A & E, or mineral supplements selenium and zinc were NOT shown to delay AMD.
Myopathy (muscle weakness and pain) and other side effects: Statins inhibit the mevalonate
pathway, which effects both the production of
cholesterol and of Q10 by over 40%. Thus
statins reduce ATP, the body’s source for energy including those that drive
bodily synthesis. In the elderly
(over 60) this effect is
pronounced. Reduction in Q10 (thus ATP)
accounts for the long list and high frequency of side effects. Statins are incompatible with the maximal
exertion of elite athletes. Myopathy
is ameliorated by Q10
is poorly tolerated by the elderly.
Physical endurance: “Results
indicate that acute and chronic
Q10 may affect acute and/or chronic responses to various types of exercise”;
confirmed in a study of elite
athletes, as “incompatible”.
Longevity: in rats
an increased maximum lifespan of 24%, and similar results obtained with
CoQ9, and mitochondria.
Recommendations: Given low
price (Costco) and safety, 300 mg
should be taken. “The
use of the aqueous suspension of
has only a minor effect.” Thus Q10 is dissolved in
oil, and thus should be taken with food. The claim that ubiquinone form is more active is
suspect since conversion from one form to another is how the body utilizes Q10.
Unfortunate there are no long-term clinical trials are population studies.
Negative studies are funded by pharma for
financial gains. However,
positive claims are supported given its role as a ubiquitous antioxidant--see
benefits above. For this reason it should be taken long-term starting by
the age of 20, even though the decline in ATP due to damage won’t be noticed
until the 6th decade, when endurance dramatically declines. Q10 should be part of healthy
diet by reducing
sugars & carbs, exercise,
learn of the corruption
worked by Pharma,
take aspirin, and post-menopause natural HRT. Q10s usage is far
greater in Japan and Europe. JK
mg daily and wishes he had
started decades earlier.
^^^^^^^^^^^^^^^^^^^^^^ Non-technical Summation
(CoQ10): recognized as the most effective antioxidant. A number of major health conditions are caused
by oxidative damage including hardening of the arteries for which Q10 is
is found in every cell in the body because it is used by the mitochondria in
the production of ATP from glucose. ATP
accounts for 95% of the body’s energy. The antioxidant
nature of Q10 derives from its energy carrier function in the production of ATP. As an energy carrier, the Q10
molecule is continually going through an oxidation-reduction cycle.
It is the
best of anti-oxidants because it is
distributed throughout the body. It
in LDL (bad cholesterol) and thus protects by preventing oxidative damage to
LDL which is the initial step in
process that results in hardening of the arteries (cardiovascular disease, CVD).
High blood pressure is a result of clogged, stiff arteries. CVD
causes over 80& of heart attacks and strokes. It protects other tissues from oxidative
damage and thereby reduces the risk for a number of serious conditions
including Alzheimer’s & Parkinson’s diseases, CVD, and macular degeneration.
The second important function is protection of the mitochondria from
damage from the reactive chemicals produced in the metabolism of glucose.
Long term usage of Q10 through protection
of the mitochondria a greater production of ATP, thus greater endurance and improved
health for the elderly. It is particular
beneficial for those with heart disease, hypertensions, diabetics; and for
those taking statins (for cholesterol), bisphosphonates (for bones), or beta
blocker (for hypertension), for these drugs partially block the bodily
production of Q10 (40% for statins)
and thus other products of the mevalonate pathway. All
these benefits from long-term Q10 add up
to an increase in lifespan and greater endurance. Q10 is not toxic: a study
found that daily dose of 3600 mg was
tolerated by both the healthy and unhealthy.
Recommendation: 100 mg for
children, being gradually increased to 300 mg by the age of 40--and its yearly
cost through Costco is under $70 for Kirkland brand Q10.