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CoQ10 supplement, for natural energy and health


  CoQ10 supplement, for natural energy and health-2 pg- - -http://healthfully.org/rc/id1.html 3/13/15


You ought to read as background the 2-page summation on the corporatization of medicine & practice of medicine.  The pharmaceutical industry (hereafter referred to as pharma) controls the research, its publication, the continuing education of doctors, etc. The perception in the press is the opposite of the truth, a truth which was succinctly stated by Harvard Prof. Marcia Angell:  “If we had set out to design the worst system that we could imagine, we couldn’t have imagined on as bad as we have.”   The lack of awareness by doctors of Q10 is a result of pharma’s control of information.   At under $100/year (Costco), given its benefits, Q10 should be taken life-long.


Coenzyme Q10 exists in 3 redox (reduced/oxidized) states:  fully oxidized (ubiquinone), semiquinone (ubisemiquinone), and fully reduced (ubiquinol).  All 3 forms are essentially bio-equivalent, though  ubiquinol has 10% greater absorption.   Coenzyme Q10 is abbreviated as CoQ10, CoQ, or Q10 is a 1,4-benzoquinone, where “Q” refers to the quinone chemical group, and 10 refers to the number of isoprenyl chemical subunits in its tail.  It was discovered in 1954, and in the 1980s there was a steep rise in clinical trials.  This oil-soluble, vitamin-like substance is present in most eukaryotic cells, primarily in the mitochondria, which is found in every cell in the body [also in LDL, HDL, & the cell membrane at].  It is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. Ninety-five percent of the human body’s energy is generated this way.  Those organs with the highest energy requirements—such as the heart, liver, [brain], and kidney—have the highest CoQ10 concentrations.  The capacity of this molecule to exist in a completely oxidized form and a completely reduced form enables it to perform its functions in the Electron Transport Chain (ETC) and as an antioxidant respectively.  CoQ10 is fat-soluble and is therefore mobile in cellular membranes; it plays a unique role in the ETC.  In the inner mitochondrial membrane, electrons from NADH and succinate pass through the ETC to the oxygen, which is then reduced to water. The transfer of electrons through ETC results in the pumping of H+ across the membrane creating a proton gradient across the membrane, which is used by ATP synthase (located on the membrane) to generate ATP[1].  This is crucial in the process, since no other molecule can perform this function. Thus, CoQ10 functions in every cell of the body to synthesize energy” (Wik).  “Q10 is synthesized from farnesyl diphosphate and tyrosine; iron, magnesium and vitamin B6 are cofactors in synthesis” at.


As an antioxidant, Q10’s also improves health.  The antioxidant nature of Q10 derives from its energy carrier function.  As an energy carrier, the CoQ10 molecule is continually going through an oxidation-reduction cycle. As it accepts electrons, it becomes reduced. As it gives up electrons, it becomes oxidized. In its reduced form, the CoQ10 molecule holds electrons rather loosely, so this CoQ10 molecule will quite easily give up one or both electrons and, thus, act as an antioxidant”(Wiki).  It is considered the best of anti-oxidants because it is distributed widely in the body and naturally serves this function with a low energy barrier, and mechanism for recycling.  Long-term usage is required for benefits, especially for reduction in damage to proteins which cause age related chronic conditions, and LDL that starts atherogenesis that causes heart disease--summary.  Peak blood level is in 2-6 hours, and second peak at about 24 hours; half-life is 33 hours. The synthesis of the precursor of coenzyme Q10, mevalonate, is inhibited by some beta blockers (blood pressure-lowering medication), bisphosphonates statins, tricyclic antidepressants and other drugs. Q10 does not interact with drugs or have side effects, and has been shown safe at 2,400 mg & 3,600 mg.


Benefits listed below are also found at total supplement Its antioxidant effect prevents the formation of plaque and thus atherosclerosis (AS) & cardiovascular disease (CVD) with their deadly consequences. 


After Heart Attack and Angina pain:  Those who took Q10 supplements starting within 3 days of a heart attack were less likely to have subsequent heart attacks, less chest pains, die of heart disease greater capacity for exercise  by 30%, also. 


Heart failure (HF):  People who have congestive heart failure, their heart isn't able to adequately pump blood, thus it pools in parts of the body, such as the lungs and legs.  “Several clinical studies suggests that Q10 supplements help reduce swelling in the legs; reduce fluid in the lungs to making breathing easier; and increase exercise capacity in people with heart failure, & reduces hospital admissions by 61%, similar, also, long-term and safety. Heart failure statin cause.


Diabetes:   improves blood sugar level 31% and also lowers high blood pressure in people with type 2 diabetes.  “In conclusion, serum Q10 levels in type 2 diabetes patients are decreased and may be associated with subclinical-diabetic cardiomyopathy reversible by CoQ10 supplementation.


High blood pressure:  In a meta-analysis of 12 clinical studies, Cochrane concluded that Q10 lowers systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by 10 mm Hg at, probably from improved heart functions.


Atherosclerosis, CVD, MI:  Q10 is the only antioxidant that attaches to LDL,  and thus slows atherogenesis, and, and. In the lab Q10 reduced “plaque formation, frequencies of ulceration, thrombosis or hemorrhage” at.  


Sperm, at Wikipedia.  “A study of idiopathic infertile men found after 26 weeks of treatment compared to the placebo cohort significant increase in sperm volume, motility, improved morphology, and seminal plasma activity.”  Also renal health, and gene expression controlling inflammation improved, also.


Cancer & chemotherapy:  Low levels of Q10 have been noted with several common cancers, thus it has been used as a supplement for cancer victims.  Several clinical studies found that Q10 help prevent damage caused by certain chemotherapy drugs, adriamycin, athracycline.  Anti-cancer immune response animal studies. 


Heart surgery:  Clinical research indicates that” introducing Q10 prior to heart surgery …  can reduce damage caused by free radicals, strengthen heart function, and lower the incidence of irregular heart beat (arrhythmias)….”


Immune system:  “Models of the immune system including phagocytic rate, antibody level, neoplasia, viral and parasitic infections were used to demonstrate that Q10 is an essential immune-modulating agent, and.


Gum (Periodontal) disease:  topical CoQ10 supplements led to faster healing and tissue repair.


Parkinson's and other neuro-degenerative diseases:  slows the progress:  “Those who took 1,200 mgs daily had 44% less decline in mental function, motor function.”   Q10 also lowers the risk of various other neurodegenerative diseases by reducing neuro-toxic insult, and, and MS and.  Long-term itlowers the risk Alzheimer’s and vascular dementia, and


Migraines:  Help prevent migraines  Thirty-one patients completed the study; 61.3% of patients had a greater than 50% reduction in number of days with migraine headache. The average number of days with migraine during the baseline period was 7.34 and this decreased to 2.95 after 3 months of therapy. Mean reduction in migraine frequency after 1 month of treatment was 13.1% and this increased to 55.3% by the end of 3 months.    


Macular Degeneration (the leading cause of blindness in seniors) Mitochondrial dysfunctions have been implicated in the pathophysiology of several age-related diseases including age-related macular degeneration (AMD), a progressive neurodegenerative disease affecting primarily the retinal pigment epithelium (RPE).  AMD may also develop in normal aging, 10–15 years after appearing in AMD patients.  CoQ10 levels in the retina can decline by approximately 40% with age.”  Moreover Vitamin A & E, or mineral supplements selenium and zinc were NOT shown to delay AMD.


Statin induced Myopathy (muscle weakness and pain) and other side effects:  Statins inhibit the mevalonate pathway, which effects both the production of cholesterol and of Q10 by over 40%.  Thus statins reduce ATP, the body’s source for energy including those that drive bodily synthesis.  In the elderly (over 60) this effect is pronounced.   Reduction in Q10 (thus ATP) accounts for the long list and high frequency of side effects.  Statins are incompatible with the maximal exertion of elite athletes  Myopathy is ameliorated by Q10 supplementation.  Statins is poorly tolerated by the elderly.


Physical endurance:  Results indicate that acute and chronic supplementation of Q10 may affect acute and/or chronic responses to various types of exercise”; confirmed in a study of elite athletes, as “incompatible”.


Longevity:  in rats an increased maximum lifespan of 24%, and similar results obtained with CoQ9, and mitochondria. 


Recommendations:   Given low price (Costco) and safety, 300 mg should be taken.  The use of the aqueous suspension of CoQ10 has only a minor effect.” Thus Q10 is dissolved in oil, and thus should be taken with food. The claim that ubiquinone form is more active is suspect since conversion from one form to another is how the body utilizes Q10. Unfortunate there are no long-term clinical trials are population studies.  Negative studies are funded by pharma for financial gains.  However, positive claims are supported given its role as a ubiquitous antioxidant--see benefits above. For this reason it should be taken long-term starting by the age of 20, even though the decline in ATP due to damage won’t be noticed until the 6th decade, when endurance dramatically declines.   Q10 should be part of healthy diet by reducing sugars & carbs, exercise, learn of the corruption worked by Pharma, take aspirin, and post-menopause natural HRT.  Q10s usage is far greater in Japan and Europe.  JK takes300 mg daily and wishes he had started decades earlier.  


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Q10 (CoQ10):   recognized as the most effective antioxidant.  A number of major health conditions are caused by oxidative damage including hardening of the arteries for which Q10 is protective.   Q10 is found in every cell in the body because it is used by the mitochondria in the production of ATP from glucose.  ATP accounts for 95% of the body’s energy.   The antioxidant nature of Q10 derives from its energy carrier function in the production of ATP.   As an energy carrier, the Q10 molecule is continually going through an oxidation-reduction cycle.  It is the best of anti-oxidants because it is distributed throughout the body.  It is found in LDL (bad cholesterol) and thus protects by preventing oxidative damage to LDL which is the initial step in the process that results in hardening of the arteries (cardiovascular disease, CVD).  High blood pressure is a result of clogged, stiff arteries.  CVD causes over 80& of heart attacks and strokes.  It protects other tissues from oxidative damage and thereby reduces the risk for a number of serious conditions including Alzheimer’s & Parkinson’s diseases, CVD, and macular degeneration.  The second important function is protection of the mitochondria from damage from the reactive chemicals produced in the metabolism of glucose.    Long term usage of Q10 through protection of the mitochondria a greater production of ATP, thus greater endurance and improved health for the elderly.  It is particular beneficial for those with heart disease, hypertensions, diabetics; and for those taking statins (for cholesterol), bisphosphonates (for bones), or beta blocker (for hypertension), for these drugs partially block the bodily production of Q10 (40% for statins) and thus other products of the mevalonate pathway.  All these benefits from long-term Q10 add up to an increase in lifespan and greater endurance.  Q10 is not toxic:  a study found that daily dose of 3600 mg was tolerated by both the healthy and unhealthy.  Recommendation:  100 mg for children, being gradually increased to 300 mg by the age of 40--and its yearly cost through Costco is under $70 for Kirkland brand Q10.   




[1] Adenosine-5'-triphosphate (ATP) is a multifunctional nucleoside triphosphate used in cells as a coenzyme. It is often called the "molecular unit of currency" of intracellular energy transfer.[1] ATP transports chemical energy within cells for metabolism.  It is used in many cellular processes, including biosynthetic reactions, motility (such as from muscle contraction), and cell division.[2] 



^^^^^^^^^ ^^^^^^^^^^^^^^^^^^^^^^   Non-technical Summation      


Q10 (CoQ10):   recognized as the most effective antioxidant.  A number of major health conditions are caused by oxidative damage including hardening of the arteries for which Q10 is protective.   Q10 is found in every cell in the body because it is used by the mitochondria in the production of ATP from glucose.  ATP accounts for 95% of the body’s energy.   The antioxidant nature of Q10 derives from its energy carrier function in the production of ATP.   As an energy carrier, the Q10 molecule is continually going through an oxidation-reduction cycle.  It is the best of anti-oxidants because it is distributed throughout the body.  It is found in LDL (bad cholesterol) and thus protects by preventing oxidative damage to LDL which is the initial step in the process that results in hardening of the arteries (cardiovascular disease, CVD).  High blood pressure is a result of clogged, stiff arteries.  CVD causes over 80& of heart attacks and strokes.  It protects other tissues from oxidative damage and thereby reduces the risk for a number of serious conditions including Alzheimer’s & Parkinson’s diseases, CVD, and macular degeneration.  The second important function is protection of the mitochondria from damage from the reactive chemicals produced in the metabolism of glucose.    Long term usage of Q10 through protection of the mitochondria a greater production of ATP, thus greater endurance and improved health for the elderly.  It is particular beneficial for those with heart disease, hypertensions, diabetics; and for those taking statins (for cholesterol), bisphosphonates (for bones), or beta blocker (for hypertension), for these drugs partially block the bodily production of Q10 (40% for statins) and thus other products of the mevalonate pathway.  All these benefits from long-term Q10 add up to an increase in lifespan and greater endurance.  Q10 is not toxic:  a study found that daily dose of 3600 mg was tolerated by both the healthy and unhealthy.  Recommendation:  100 mg for children, being gradually increased to 300 mg by the age of 40--and its yearly cost through Costco is under $70 for Kirkland brand Q10.   

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As for a rebound effect from discontinuation of Q10, that hasn’t been reported, nor has the research addressed that possibility.  Since Q10 is at the end of a pathway which produces farnesyl-PP, and this is used to synthesize 7 essential families of compounds including heme A, Q10, sterol, cholesterol, and dolichols, the production of farnesyl-PP will not be significantly diminished by Q10 suppliment since it is only one of many end products.  Q10 production may be less for a few days if the supplement is stopped.  Farnesyl-PP is converted to Q10 where needed, thus serum level is naturally low and an increased level from exogenous source will have little effect upon the production of farnesyl-PP. 






Parkinson Disease: The plasma level reached a plateau at the 2400 mg/day dosage and did not increase further at the 3000 mg/day dosage. Our data suggest that in future studies of coenzyme Q10 in PD, a dosage of 2400 mg/day (with vitamin E/alpha-tocopherol 1200 IU/day) is an appropriate highest dosage to be studied.  http://www.sciencedirect.com/science/article/pii/S0014488604001761


2008 UK study http://ukpmc.ac.uk/abstract/MED/17200487


 

Oil-based 90mg/day capsule elevated Q10 in plasma by 178% and in VLDL+LDL fraction by 160%. http://www.sciencedirect.com/science/article/pii/S0891584996005497





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Disclaimer:  The information, facts, and opinions provided here is not a substitute for professional advice.  It only indicates what JK believes, does, or would do.  Always consult your primary care physician for medical advice, diagnosis, and treatment.