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Hypertension, bad pharma treats a sign, thus not a cause


In the 1931, John Hay, Professor of Medicine at Liverpool University, wrote that "there is some truth in the saying that the greatest danger to a man with a high blood pressure lies in its discovery, because then some fool is certain to try and reduce it".  This view was echoed by the eminent US cardiologist Paul Dudley White in 1937, who suggested that "hypertension may be an important compensatory mechanism which should not be tampered with, even when it’s certain that we could control it."  Charles Friedberg's 1949 classic textbook "Diseases of the Heart", [10] stated that "people with 'mild benign' hypertension ... [defined as blood pressures up to levels of 210/100 mm Hg] ... need not be treated"[8]  Wiki.   In 90% of the cases the underlying cause of hypertension is atherosclerosis (hard, swollen arteries).  The heart is attempting to supply sufficient blood/oxygen to the vital organs, thus the blood pressure rises.  Lowering the oxygen supply to these organs lowers the vitality including cognitive function of the patient.  Plus drugs that lower blood pressure don’t significantly lower the risk of heart attacks because hypertension is a sign of atherosclerosis, not its cause. 


 


The paper below starts with a discussion bad pharma and its pitch for treating hypertension; it then applies what has been learnt to other elements of cardiovascular disease (high cholesterol and endothelial dysfunction).  This paper ends with how to stop the progression of atherosclerosis and thereby lower the risk for heart attacks and strokes—and also blood pressure and weight.    


Two questions: 


Do you want to take several weird, under-tested chemicals sold on a sham claim of health benefits?

 

Do you want to experience significant decline in cognitive function, physical and sexual performance? 



 


 


Treating the symptom of hypertension with drugs  http://healthfully.org/rc/id24.html  10/9/15 

Learn of hypertension as a sham condition, of cholesterol myth, of causes for atherosclerosis, of bad pharma, and healthful medical science

Associated with doesn't entail cause.  Firemen are often found at fires; that doesn't prove they cause fires.  Kidney damage is associated with hypertension, not caused by it.  That is because hypertension is caused by atherosclerosis (stiff, swollen arteries full of plaque that contains fibrous cells, lipids, lymphocytes, and calcium).  But instead of treating atherosclerosis that causes the ischemic events, pharma treats hypertension.  It is like treating fever instead of the flu.  

 

Ischemia (ischemic events) occurs when there is a restriction of the blood supply causing a shortage of oxygen and glucose needed for cellular metabolism to keep the tissue alive.  It can be caused by vasoconstriction, embolism, or thrombosis.  The first two account for less than 10% of those events.  The third, thrombosis, is caused almost entirely by young soft plaque leaking from an artery interior wall and this leaked plaque can cause by blocking supply of blood the destruction of tissue.  If the thrombosis caused ischemic events occur in the heart and destroys sufficient muscle it is called a myocardial fraction (heart attack), destroys sufficient neuron a stroke.  These events can occur in arterioles (small arteries) and be subclinical events.  Thus an angina pain could be a small ischemic event.  And some bouts of disorientation are caused by mini-ischemic events in the brain.  Often these mini-events go unnoticed.  However if they occur frequently in the brain (where there is no pain receptors) it causes the second most common form of dementia, vascular dementia.  If these mini-ischemic events occur often enough in the kidney, it causes kidney dysfunction.  And the same occurs in other tissues; of note is the eyes, bowels, limbs, under the skin, but not limited to these tissues.    

 

Because of their side effects, to treat hypertension with drugs causes more problems than it prevents.  Based on industry funded studies (which have Positive bias by design—see Prof. Prof. Ben Goldacre’s Bad Phama) the reduction in major coronary events using pharm short-term studies is at best is not statistically significant for beta blockers, ACE inhibitors , Angiotensin II receptor antagonists, and calcium channel blockers,  so found the prestigious Cochrane Review and Worst Pill, and thus negative when side effects are considered.  But doctors don’t know enough about the biology behind the processes of hypertension because their medical textbooks and continuing education is written and given by pharma’s KOLs (key opinion leaders), and they rely on-pharma generated guidelines for clinical decisions, thus they treat the sign of atherosclerosis, hypertension, with drugs rather than the causes of atherosclerosis. 

 

The web of deceit on causes of coronary events has been carefully woven:  hypercholesterolemia is another bystander.  It is only very weekly associated with coronary events.  For example the Framingham Study found that the elderly with high cholesterol had less coronary events and lived longer than those with low cholesterol (Prof. Uffe Ravnskov, Ignoring the Awkward! p 36). The surrogate outcome of statins lowering cholesterol is not associated with fewer ischemic events, and their side effects are significant.  Yet Braunwald’s cardiology textbook repeats the mantra that “statins are safe and effective.”   Unfortunately, for doctors and the public pharma frames the discussion of cardiovascular disease.  It is for the sales of drugs—as Prof. Peter Gotzsche states below.   Even those who know better, they avoid this topic or give it lip-service rather than lose their audience.  Thus the chorus of critics of the cholesterol hypothesis is small, but their evidence convincing.  

 

It is as Prof. Peter Gotzsche wrote:  “Whatever the industry does, whatever it calls it, and whatever it says about its noble motives, it all boils down to one thing:  selling drugs. “  Deadly Medicines and Organised Crime:  how big pharma has corrupted healthcare p. 87.  Most of what pharma writes is through KOLs.  To be a KOL entails receiving large sums for services to pharma.  More complete is the statement by Dr. Evens in The Guardian:  “The pharmaceutical industry is the most lucrative, the most cynical and the least ethical of all the industries. It is like an octopus with tentacles that has infiltrated all the decision-making bodies:  World Health Organizations, government agencies, parliaments, high administrations in health and hospitals and the medical profession." He is the author of "The Guide to the 4,000 Useful, Useless or Dangerous Medicines" (Sept 2012), with Dr. Bernard Debre is director of the prestigious Necker Institute; Dr. Philippe Even is a member of the French Parliament. F. Pharma.  It is as Prof. Marcia Angell, Harvard:  states:  “The 800 pound gorilla can do whatever it wants” (referring to the $800 billion dollar industry).  Her excellent 77 minute lecture on pharma proves the quotes above.  It is at http://www.youtube.com/watch?v=ZqKY6Gr6D3Q. 

From my email response to a friend’s phone call about a doctor’s visit (10/9/15):  Thanks for telling me how your doctor is selling the high-blood pressure medications.  It is helpful to me to learn how doctors sell pharma's drugs.  They sell the benefits and hide the side effects (assuming they have been informed adequately about them).  Thus you were told that hypertension causes heart attacks and kidney dysfunction in your visit yesterday.  Pharma’s sales pitch has two flaws:   biological and results of treatment.  So put your thinking cap on and follow my evidenced base account of the complex web of biological & results deceptions. 

 

What you and nearly every person over the age of 60 get following a physical is a strong recommendation from their physician to treat with a drug some putative sign of cardiovascular disease.   What I wish to convey to you is that with very few exceptions these drugs are treating symptoms rather than the underlying causal condition.  Treating signs is not effective, and thus not worth their side effects.  I have spent 11 years since healthfully.org was born looking into medical issues and the methods of pharma.  Moreover I have been reading medical literature since 1972 and came to it with a strong science background.  I am warning you about the bullshit based upon tobacco science that pharma teaches physicians, and I will also presenting to you what medical science has uncovered concerning cardiovascular disease.  It is as Prof. Peter Gotzsche wrote:  “Whatever the industry does, whatever it calls it, and whatever it says about its noble motives, it all boils down to one thing:  selling drugs.“  Deadly Medicines and Organised Crime:  how big pharma has corrupted healthcare p. 87.  His book meticulously adds flesh to how big pharma has corrupted healthcare. 

 

4) In what follows I will show you how much big pharma has corrupted the science behind cardiovascular disease for to sell their drugs.  I will start with hypertension (your concern Danny), then hypercholesterolemia, followed by endothelial dysfunction and end with the major causes for atherosclerosis and thus cardiovascular disease. You will arrive at where you started and know the healthful path for the first time. 

 

Associated with doesn't entail cause.  Firemen are often found at fires; that doesn't prove they cause fires.  Kidney damage is associated with hypertension, not caused by it.  That is because hypertension is caused by atherosclerosis (stiff, swollen arteries full of plaque that contains fibrous tissue, lipids, lymphocytes, and calcium).  When plaque leaks it can damage the kidneys.  But instead of treating atherosclerosis that causes the ischemic events, pharma treats hypertension.  It is like treating fever instead of the flu.  

 

Ischemia (ischemic events) occurs when there is a restriction of the blood supply causing a shortage of oxygen and glucose needed for cellular metabolism to keep the tissue alive.  It can be caused by vasoconstriction, embolism, or thrombosis.  The first two account for less than 10% of those events.  The third, arterial thrombosis is caused almost entirely by young soft plaque before a hard fibrous cap forms over the plaque.  It leaks through the endothelial cells that line the artery, and this leaked plaque can block the flow of blood to cause the destruction of tissue.  If the thrombosis-caused ischemic events occur in the heart and destroys sufficient muscle it is called a myocardial fraction (heart attack, MI); destroys sufficient neuron a stroke.  These events can block arterioles (small arteries) and result in subclinical events.  Thus an angina pain could be a small ischemic event; and some bouts of mental disorientation could be mini-ischemic events.  Often these mini-events go unnoticed.  If they occur frequently in the brain (where there are no pain receptors) it causes the second most common form of dementia, vascular dementia.  If these mini-ischemic events occur often enough in the kidney, it causes kidney dysfunction.  And the same occurs in other tissues; of note is the eyes, bowels, limbs, under the skin, but not limited to these tissues.   Leaking plaque is caused by atherosclerosis, not hypertension.  Thus as expected lowering blood pressure doesn’t significantly lower the frequency of events—though pharma claims it does.  So what are we to make of pharma’s claims?

 

First the FDA permits the surrogate outcome of lower blood pressure; but we take antihypertensive drugs to prevent major events.  Second to avoid negative results very, very few pharma-funded studies use as endpoints just deaths and heart attacks.[1]  This claim of benefits is based on industry funded studies (which have Positive bias by design and gross manipulation of results—see Prof. Prof. Ben Goldacre’s Bad Phama).  Even so these shoddy short-term studies by pharma (what I call tobacco science) do NOT result in a statistically significant reduction of major coronary events for beta blockers, ACE inhibitors , Angiotensin II receptor antagonists, and calcium channel blockers,  so found the prestigious Cochrane Review and Worst Pill; thus these drugs are not worth their side effects.[2]  The worst of these pharma studies (not used by Cochrane and Worst Pill in their analysis) are used to market these drugs and justify treatment guidelines.  What we know about antihypertensive drugs and pharma, this is their business model—“all about sales”.    

 

8) The web of deceit on causes of coronary events has been carefully woven:  hypercholesterolemia is another bystander.  High cholesterol is only very weakly associated with coronary events.  For example the Framingham Study found that the elderly with high cholesterol had less coronary events and lived longer than those with low cholesterol (Prof. Uffe Ravnskov, Ignoring the Awkward! p 36). The surrogate outcome of statins lowering cholesterol is not associated with fewer ischemic events, and their side effects are significant.  Yet Braunwald’s cardiology textbook repeatedly states the industry’s mantra that “statins are safe and effective.”  For the doctors and the public, pharma frames the discussion of cardiovascular disease.  It is all for the sales of drugs as Prof. Peter Gotzsche states.   Even those who know avoid this topic or give it lip-service rather than lose their audience.  Thus the chorus of critics of the cholesterol hypothesis is small, but their evidence convincing.  Enter in the Amazon website cholesterol myth and you will find over 50 books thereon.


So what is driving the development of atherosclerosis and thus myocardial fractions?   Endothelia cells are the gatekeepers for what enters the tissues that make up the arteries.  Thus damage to them--termed endothelial  dysfunction-- promotes the entering of substances into the artery tissue that cause atherosclerosis.  Endothelia dysfunction has 5 main causes:  1) high level of blood sugar especially the 7 times more reactive fructose (thus heart attacks are associated with diabetes and the Western diet) through the process of glycation,[3] which damages the endothelial cells.  2) Fructose is converted to fat in the liver.  Too much fructose with too little exercise results in a fatty liver.  A fatty liver mucks up the metabolic regulatory system to cause insulin resistance and thus weight gain.  Among its many effects is a higher level of blood sugars; thus through glycation damages endothelial cells.  3) A diet high in trans-fats and polyunsaturated fats (polyunsaturated fats are subject to a process of rancidification in the body and on the shelf).  Their abnormal shapes adversely affect the cell walls of the endothelial cells.  4) Carbon monoxide and other reactive chemical in the blood which can bond to the endothelial cells (similar to fructose and glucose).  5) Infectious agents through their toxins circulating in the blood damage the endothelial cells and thereby permit the penetration of pathogens into the tissue within the arteries.  Infectious agents in the artery walls have been clearly shown to be the major cause of plaque formation through an immune response to their presence.[4]  In conclusion, the five processes which damage the endothelial cells are atherogenic.   

 

Young immature plaque is similar to a boil, both are caused by infection.  When the young plaque leaks it can cause a thrombosis.  Evidence for the role of pathogens goes back over 100 years: “There is every indication that the production of tissue in the intima [inner layers of artery wall] is the result of a direct irritation of that tissue by presence of infection or toxins.”[5]  There are hundreds of published journal articles, see these links and, or enter into Google scholar and enter atherosclerosis + pathogens.  Similarly articles prove the other causes:  enter glycation + endothelial dysfunction, trans- fats + endothelial dysfunction, and rancid + polyunsaturated fats.[6]  Thus we can see that the Western diet with its unhealthy fats, refined carbohydrates and loads of sugars (US average is 151 pounds) which lead to metabolic dysfunction resulting in insulin resistance and fatty liver disease, and cigarettes are driving forces in endothelial dysfunction.  Thus to reduce the risk of atherosclerosis and its comorbidities, we must reduce the risk for endothelial cell damage. 

 

We have as problems not just the high sugar (fructose being the worst sugar), but also another example of profits before health.  Polyunsaturated fats are cheap, so too is their conversion to saturated fats by hydrogenation to improve the flavor of foods—a byproduct are trans-fats.  These fats are favored by food manufacturers, thus the widely held belief that they are healthful, and the more expensive saturated fats are unhealthful.  It turns out that the expensive saturated fats and monounsaturated fats are the best for health—see fats for the very convincing evidence.  And it get worse, the transfats made from these polyunsaturated fats through a process of hydrogenation have been proven to promote cardiovascular disease.  A number of countries have totally banned them, the US has created exclusion for business and then doesn’t inforce the labeling requirement but relies upon the food manufacturer to inform the public of their presence.  Again the saying of Prof. Gotzsche rings true:  “it all boils down to one thing, the selling of drugs” or in this case that of the cheaper polyunsaturated fats and the hydrogenated fats derived therefrom.   In a system which measures performance by profits, it is more profitable to manipulate beliefs than to do the right thing. 

 

Like so much else, the popular “wisdom” on diet fails—as proven by the current pandemics.  I have spent 2 years (10-2013 to 10-2015) examining the obesity and diabetes pandemics and their role in promoting cardiovascular disease.  The main cause of these conditions is diet, and thus the main fix and prevention lies with diet.  I have arrived at an evidenced based dietary fix for preventing and reversing endothelial dysfunction, insulin resistance and fatty liver disease--click on link and long version.  The regulatory and information systems are broken. 

 

Most of what pharma writes is through KOLs (key opinion leaders).  To be a KOL entails receiving large sums for services to pharma—not employees.  In our corporatist world, the 800 pound gorilla can do pretty much anything it wants” as Harvard Prof Marcia Angell states (a reference to the $800 billion industry).  More complete is the statement by Dr. Evens in The Guardian:  “The pharmaceutical industry is the most lucrative, the most cynical and the least ethical of all the industries. It is like an octopus with tentacles that has infiltrated all the decision-making bodies:  World Health Organizations, government agencies, parliaments, high administrations in health and hospitals and the medical profession." He is the author of "The Guide to the 4,000 Useful, Useless or Dangerous Medicines" (Sept 2012), with Dr. Bernard Debre is director of the prestigious Necker Institute; Dr. Philippe Even is a member of the French Parliament--F. Pharma.  Prof.  Angell’s  77 minute lecture confirms these quotes, at http://www.youtube.com/watch?v=ZqKY6Gr6D3Q. 

 

For more on hypertension, http://healthfully.org/rl/id1.html, atherogenesis http://healthfully.org/rl/id2.html and http://healthfully.org/rl/id8.html, high dose aspirin treatment http://healthfully.org/rc/id17.html and dietary treatments http://healthfully.org/rh/id12.html of atherosclerosis (the high sugar Western diet causes endothelia dysfunction which  is causally associated with atherosclerosis), and for the cholesterol myth watch the Australian Broadcast corporation at https://www.youtube.com/watch?v=Sa9ZYsW59Zo, and on my website are numerous articles on statins, the cholesterol myth, the major causes for atherosclerosis.  They can be found through the Google-internal search engine on each home page--one article on the cholesterol myth is at http://healthfully.org/rl/id5.html.

 



[1]   It is actually much worse than that.  The aim of drug regulation is to ensure that only effective and safe treatments reach patients. Ideally, regulatory decisions are based on good quality data from large trials measuring real world, patient centred outcomes. Licensing agencies, however, routinely approve treatments on the basis of small placebo controlled trials evaluating short term, surrogate endpoints in selected populations. Consequently, medicines are commonly prescribed without good quality data on their long term benefits and harms.  Current licensing standards are inadequate to predict the real world therapeutic value of new medications. Sept 9, 2015, British medical Journal, Dr. Huseyin Naci http://www.bmj.com/content/351/bmj.h5260?etoc= 

[2] The reporting of side effects is another sham government fix.  For details click on link and on sham FDA  oversight. 

[3]  Glycation is the non-enzymatic bonding of sugars to lipids and proteins.  This bonding is damaging to the endothelial cells that line the arteries—more so than to the short-lived red and white blood cells. 

[4] Pharma with their tobacco science claims that atherosclerosis is caused by damage LDL that causes an immune response.  This is far fetch (see Ravnskov supra) are click on link.  LDL not only transports cholesterol and fat, it also functions as part of the immune system.  That is why it is found in plaque.  Numerous journal articles make both points; click on this link and for a few of the published journal articles.  Thus we have 2 distortions, that concerning pathogens and that on the function of LDL. 

[5] Klotz O, Manning Mf, Journal of Pathol Bacteriol, 1911;16:211-220. 

[6] Trans and oxidize polyunsaturated fats are unnatural, thus our body lacks the enzymes to metabolize them.  Fats are also utilized in the formation of cell walls.  The incorporation of these abnormal fats in the walls adversely affects the functions of endothelial cells.  This is particularly significant with endothelial cells in the arteries and arterials in that they act as gatekeepers for the entrance through active transport of chemical, lymphocytes, bacteria, cholesterol, and other substances into the underlying tissues.  Thus these abnormal cells promote through the penetration of pathogens which casue the immune process leading to atherosclerosis.  This damage to the cells also occurs through glycation (sugar bonding to endothelial cells) and reactive chemicals such as carbon monoxide from cigarettes.  This explains why diabetes doubles the risk of heart attacks, as does the long-term smoking.   


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Disclaimer:  The information, facts, and opinions provided here is not a substitute for professional advice.  It only indicates what JK believes, does, or would do.  Always consult your primary care physician for medical advice, diagnosis, and treatment.