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Summary and index on Conditions and their treatments


http://healthfully.org/rg/id4.html IDEAS TO INCLUDE   7/3/18


Outline of the subsequent article


This section of the website is the product of over 40 years of investigation on what is good and bad in health care and diet, which was stepped up when I established healthfully.org in 2004—link for my qualifications.  Though based on my search and focus I stand on the shoulder of others—link bio page.  This section, on page 1 is my introductory section to the various sections.  Page 2 is on our high fructose diet and its consequences.   Page 3 is a continuation of the case against sugar/fructose, page 4 is on the 5 biggest families of drugs.  Page 5 is on other bad drugs/treatments.  Page 6 is on the methods of bad pharma .  Page 7 is on books. 8 on links to seminal articles on this website; 9 the documentaries and lectures with links—each with a very short description and rating. 


Total 47 pages 6/30/18 (5/30 39 pages)


I.   Evidence for Conditions Associated with the Western Diet (CAWD)


II.   How Fructose Causes Insulin Resistance


III. Consequences of Insulin Resistance (IR)


IV. How excess fructose causes CAWD


V,  Diabetes a window on causes of CAWD


VI.   The Error in blaming elevated glucose for the comorbidities of t2d, obesity, and MeS, -- association doesn’t prove causality


VII. The error of blaming palmitic acid or other saturated fats for CVD


VIII.  Prevention and signs of insulin resistance


IX.    Dietary fix


I.     Evidence for Conditions associated with the western diet (CAWD) and misinformation


  1. Conditions linked to RAGE

  2. Hyperglycemia, saturated fats, and cholesterol—the scapegoats

  3. Basic explanation

  4. Sources of material on CAWD, LSP and fructose

  5. Cognitive dissonance and framing beliefs

  6. Cognitive dysfunction

  7. Health biomarkers of those on a traditional diet

  8. IR and fructose


II.     How Fructose causes insulin resistance Introduction


  1. Introduction

  2. Metabolized by the liver

  3.  Fructosylation of proteins

  4.  Fatty Liver

  5.  Two hit hypothesis for NAFLD & hepatic inflammation

  6.  Uric acid from fructose metabolism promotes IR

  7.  Defective mitochondria 

  8.  Inflammation in the liver

  9.  Insulin resistance in the liver

  10.  Insulin resistance in other tissues

  11.  Fatty pancreas causes t2d

  12. Metabolic syndrome (MeS)

  13.  Fatty pancreas causes t2d

  14. Not refined grains (glucose)

  15. Summation


III.    Consequences of IR


  1.  A review of the role of excess fructose

  2.  Fat storage

  3.  Weight regulatory system

  4.  Leptin and leptin resistance

  5.  Cellular hyperglycemia

  6.  Type-2 diabetes

  7.  Elevated insulin like growth factors

  8.  Downstream changes caused by IR

  9.  Fetal environment promotes IR


                 


IV.     How excess fructose causes CAWD


  1. Introduction

  2. Insulin resistance

  3. Defective mitochondria

  4. Hyperuricemia & uric acid crystal (gout)

  5. Fructosylation and cytotoxicity

  6. Polyol pathway produces sorbitol then fructose, thus cellular fructosylation

  7. Low ascorbate in the polyol pathway

  8. Cellular osmotic pressure from excess glucose and fructose production

  9. LSP on high carb diet avoid CAWD, why?

  10. Under-production and oxidative damage to collagen

  11. Fructosylation of collagen

  12. Hypoxia and defective mitochondria

  13. Endothelial dysfunction, atherosclerosis, and peripheral artery disease

     


V.    Diabetes as a window on causes of CAWD   


a.  Introduction


b.  Defective mitochondria


c.  NADP depletion


d.  Lower NO (nitric oxide)


e.  Microbiome


f.  Fructosylation


g.  Hyperosmolar hyperglycemic state (HHS)


h.  Uric acid


i.   Collagen underproduction


j.   Endothelial dysfunction, atherosclerosis, and peripheral artery disease


k.  Cortisol


l.  mTOR


m.  Summation


 


VI  Blaming elevated glucose for the comorbidities of t2d, obesity, and MeS


a.  Evolutionary question                                                                                               b.  Glycation by glucose is not a major cause for CWD and other CAWDs                      c.  An historical prospective                                                                                               d.  Fructose is safer than sugar for diabetic and doesn’t cause MeS--Wikipedia


 


VII  The error of blaming palmitic acid or other saturated fats for CVD


  1. What doesn’t work:  eat less and move more

  2. Obesity and t2d are dietary problems with a dietary fix

  3. Mediterranean diet

  4. Good and bad fats

  5. The dietary fix


VIII  Prevention and signs of  insulin resistance


  1. Prevention

  2. How to tell if you are insulin resistant


XI  Dietary fix  IR, t2d, obesity, fatty liver, TOFI and CAWD


  1.  What doesn’t work:  eat less and move more

  2. Obesity and t2d are dietary problems with a dietary fix

  3. Mediterranean diet

  4. Good and bad fats

My medical background consists of purchasing medical textbooks starting in 1971 for studying, and reading journal articles.  My academic qualification is 11 years of university training in liberal arts and sciences including, 2 years of graduate school in philosophy.  Having a faith in critical analysis that searches for the best answers and enjoying exploration, I continued to explore a wide assortment of topics as a leisure time activity.  In 2001, I started to put the products of that exploration on 3 websites.  Before YouTube became popular, I had a peak average of 15,000 pages downloaded daily.  Healthfully.org was started in 2004.  The sites had as a theme correcting errors in beliefs which therefore entailed arriving at the best evidence based conclusion.  For a page on my background. 



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What can the 1,300 pound gorilla do, pretty much anything it want--prof. Marcia Angell, Harvard

DISCLAIMER:  As Ben Franklin said, we all keep our own time; thus what I write is what I believe & thus would do; however, I am not recommending others to violate clinical guidelines or their doctors’ recommendations