List of Top 10 Drug Warnings and Recalls of 2007

Fiercepharma.com November 29, 2007

at http://www.fiercepharma.com/special-reports/top-10-drug-warnings-and-recalls-2007

1. Antidepressants - Various companies

2. Epogen/Aranesp - Amgen

3. Zyprexa - Eli Lilly

4. Avandia - GSK

5. Actos - Takeda

6. Provigil - Cephalon

7. Zelnorm - Novartis

8. Byetta - Amylin

9. Xolair - Genentech

10. Fentora - Cephalon

1.  2006 sales: $20.6 billion

Manufacturer: Various

Safety concern: “black box,” suicidal thoughts in young adults

Other conerns, fail to work better than a placebo when the studies are properly done free of big PhARMA mnaipulation—see graph.  

2.  Drug: Epogen/Aranesp

2006 sales: 4.1 B/$2.5 B

Manufacturer: Amgen

Safety concern: “black box;” heart and vascular problems at higher doses

3. Drug: Zyprexa

2006 sales: $4.4 billion

Manufacturer: Eli Lilly

Safety concern: Warning; weight gain, metabolic problems

Eli Lilly settlement with 18,000 patients for $500 million

4, Drug: Avandia

2006 sales: $3.4 billion

Manufacturer: GlaxoSmithKline

Safety concern: “black box;” heart failure, heart attack

5. Drug: Actos

2006 sales: $3.05 billion

Manufacturer: Takeda

Safety concern: “black box;” heart failure

6.   Drug: Provigil

2006 sales: $727 million

Manufacturer: Cephalon

Safety concern: Warning; Stevens-Johnson syndrome, psychiatric problems

7.   Drug: Zelnorm

2006 sales: $561 million

Manufacturer: Novartis

Safety concern: Recall; heart risks

8.  Drug: Byetta

2006 sales: $430 million

Manufacturer: Amylin

Safety concern: Precautionary language , pancreatitis

9.   Drug: Xolair

2006 sales: $425 million

Manufacturer: Genentech

Safety concern: "Black box,” anaphlaxis

10.  Drug: Fentora

2006 sales: $370 million

Manufacturer: Cephalon

Safety concern: Warning; improper dosing leading to death