THE HEART

Home | 2-PAGE SUMMATION ON STATINS | Understanding Atherosclerosis & its MI Link--jk | understanding heart attack | lipids, lipoproteins, the basics | ABOUT Cholesterol | Tables of Risk Factors plus STATS | Niacin prevents MI 25% | Statins, inflammation & atherogenesis--their failure | inflammation, obesity and atherosclerosis | Risk Factors Athereosclerosis | High Cholesterol and treatments | STATINS, lowering cholesterol doesn't prolong life | MMP role in atherogenesis and statins | COX-2 Suppression and statins | High HDL not Prophylactic | Other Markers for Cardiovascular Disease | $70,000 standard heart treatment per year following a MI | Why improving cholesterol profile with statins has little effect | Statins side effects | Statins over prescribed | Recommendation for your heart | New Major Study Pans Statins | STATIN COMBO STUDY, NO BENEFITS | C-Reactive Protein and Statins | Ozone & cholesterol combine to cause heart disease | Calcium score and coronary disease--a review | Serious cognitive impairment from bypass operation, Scientific American | ARRHYTHMIA, sudden early death and prevention for relatives | STEM CELLS GROW HEART MUSCLE | BYPASS & STENTS over sold

Tables of Risk Factors plus STATS




There has been in the last 3 years numerous changes and additions to the healthful website as JK realized the extent of corruption worked by pharma on the evidence base.  Major revision in causes of heart disease. 


Two Changes in content coming up


  1. The cholesterol myth.  Numerous critics have pointed out that cardiovascular disease is not caused by higher levels of blood cholesterol or fats.  Pharma promotes the cholesterol myth and ignores the major causes.

  2. Major cause of cardiovascular disease is pathogens living within the middle layer of artery walls.  It initiates the immune response which involves LDL, HDL, and white blood cells.  Reactive chemicals such as simple sugars and carbon monoxide can potentiate the process resulting in the formation of plaque within the artery walls.

     


For confirmation from journal articles on primary role of infective agent enter into http://scholar.google.com/ terms such as bacteria + atherosclerosis or go to http://healthfully.org/rl/id8.html and id9  for collection of articles


For confirmation of cholesterol myth enter into http://scholar.google.com/ or http://www.amazon.com/ cholesterol myth, or go to http://healthfully.org/rl/id5.html for collection of journal articles. 


 


The article below was done in 2009, before JK discovered the extent of the corruption worked by pharma.  Much of what has been stated here was based upon a reliance of pharma’s opinion leaders.  The recommended section of this website has a far better analysis—see http://healthfully.org/rc/  





< less than           > greater than

 

Date

HDL

LDL

Chol

LDL/HDL

Chol/HDL

Triglycer

ides

Blood

Pressure

Fasting

glucose

1

 

>40

<130

<200

>6.0 high

<3.0 low

 

<130 <200

30-110

>130

>110

2

M-good

>60

<100

 

3-6 high

 

<150

>130

>110

3

Desirable

>40

100-129

<200

 

 

<150

 

 

4

borderline

 

130-159

200-239

 

 

150-199

 

 

Row 1 from blood work; rows 2, 3 & 4 from Merck

 

                                    FRAMINGHAM RISK TABLES FOR MEN

Age

20-34

35-39

40-44

45-49

50-54

55-59

60-64

65-69

70-74

75-79

Age points

-9

-4

0

3

6

8

10

11

12

13

TC <160

0

 

 

 

 

 

 

 

 

 

160-199

4

 

 

 

 

 

 

 

 

 

200-239

7

 

 

 

 

 

 

 

 

 

240-279

8

 

 

 

 

 

 

 

 

 

>280

11

 

 

 

 

 

 

 

 

 

Nonsmoker

0

 

 

 

 

 

 

 

 

 

Smoker

8

 

 

 

 

 

 

 

 

 

HDL >60

 

 

 

 

-1

 

 

 

 

 

50-59

 

 

 

 

0

 

 

 

 

 

40-49

 

 

 

 

1

 

 

 

 

 

<40

 

 

 

 

2

 

 

 

 

 

BP <120

 

 

untreated

0

treated

0

 

 

 

 

120-129

 

 

untreated

0

treated

1

 

 

 

 

130-139

 

 

untreated

1

treated

2

 

 

 

 

140-159

 

 

untreated

1

treated

3

 

 

 

 

POINTS 10-year risk of MI or CAD death %:   <0 = <1%;   0-4 = 1%;   5-6 = 2%;   7 = 3%;

            8 = 4%;   9 = 5%;   10 = 6%;   11 = 8%;   12 = 10%;   13 = 12%;   14 = 16%;

            15 = 20%; 16 = 25%; >17 = > 30%      

< less than           > greater than

 

                                    FRAMINGHAM RISK TABLES FOR WOMEN

Age

20-34

35-39

40-44

45-49

50-54

55-59

60-64

65-69

70-74

75-79

Age points

-7

-3

0

3

6

8

10

12

14

16

TC <160

0

0

0

0

0

0

0

0

0

0

160-199

4

4

3

3

2

2

1

1

1

1

200-239

8

8

6

6

4

4

2

2

1

1

240-279

11

11

8

8

5

5

3

3

2

2

>280

13

13

10

10

7

7

4

4

2

2

Nonsmoker

0

0

0

0

0

0

0

0

0

0

Smoker

9

9

7

7

4

4

2

2

1

1

HDL>60

 

 

 

 

-1

 

 

 

 

 

50-59

 

 

 

 

0

 

 

 

 

 

40-49

 

 

 

 

1

 

 

 

 

 

<40

 

 

 

 

2

 

 

 

 

 

BP <120

 

 

Untreated

0

 

Treated

0

 

 

 

120-129

 

 

Untreated

1

 

Treated

3

 

 

 

130-139

 

 

Untreated

2

 

Treated

4

 

 

 

140-159

 

 

Untreated

3

 

Treated

5

 

 

 

>160

 

 

Untreated

4

 

Treated

6

 

 

 

POINTS (10 yr. Risk of MI or CAD death %):   <9 point = 1%;   9-12 = 1%;   13-14 = 2%;

    15 = 3%;    16 = 4%;   17 = 5%;   18 = 6%;   19 = 8%;   19 = 8%; 20 = 11%;

                 21 = 14%;   22 = 17%;   23 = 22%;   24 = 27%; 25 = >30%

< less than           > greater than

 

 

HEART STATS

American Heart Association

For tables of heart disease factors (43 pages—would copy to web page) http://www.americanheart.org/downloadable/heart/1200078608862HS_Stats%202008.final.pdf

 

Fat consumption is 33% of total calories with saturated fats being 10.8%.  Meat averages 200 pounds per person per year. 

 

Catheterizations 1,322,000 annually, 604,502 hospital discharges, with average stay of 3.6 days.  In 05 there were 469,000 coronary artery bypass procedures preformed on 261,000 patients. In 06 2,192 heart transplants, with 24.7 were younger than 35.  1,265,000 Percutaneous Coronary Interventions (PCI) (angioplasty).  Costs for 04 were for bypass $85,653, PCI $44,110; Catheterization $25,322, pacemaker $43,101; implantable defibrillator $99,845, endarterectomy $22,037, valves $119,918.    Since 1965 smoking has declined 50%.  Smoking was 43.2% for those with 9-11 years of education and 7.1% for those with more than 16 years.  46,600,000 smokers in 05 (25.9 males and 20.7 females). 

 

From 1997-2001, an estimated 438,000 Americans died each year of smoking-related illnesses, of which 34.7% were from cardiovascular disease.  On an average, male smokers die 13.2 years earlier than nonsmokers and females 14.5 years earlier than female nonsmokers.  Smoking caused 3.3 million years of lost for men, and 2.2 million for women.  Cigarette smoking results in a two-to-three-fold risk of dying from coronary heart disease.  Use of tobacco products in 2004 was 31.4% for whites, 11.7% for Asians, 23.3% for Latinos. 

 

In 2005 106,700,000 had total cholesterol of 200 mg/dL (age 20 and older), or 48%, and for above 240 mg/dL, 37,200,000 or 17%.

 

Overweight children 2-5 years 10.3% were overweight in 04; 6-11 years increased from 4% in 71 to 17.5% in 04.  ADULTS, 142,000,000 were overweight (73M males, and 69M females) which is 66% of adult population, of which 31.4% were obese BMI of 30 or greater).  Diabetes mortality in 04 was 225,400, which is 2-4 times higher than those without diabetes.  Lifetime risk of stroke goes from 1.8 to 6%.   

 

High blood pressure in 05, 73M (1 in 3 adults), (33.4M men, 39M women) untreated systolic pressure of 140 mm Hg or higher, or diastolic pressure of 90 mm HG or higher.  This results in a 1.5 times greater rate of heart disease and a 4.2 times rate of end-stage kidney disease.  Elder women (over 75) have an 83.8 incidence and men a 69.5% incidence of HBP.

 

CORONARY HEART DISEASE (CHD):  in 05 was 16M of which 8.7M were men and 7.3M women and there were 770,000 new coronary attacks and 430,000 recurrent attacks, and another 190,000 silent first heart attacks.  Of these 600,000 were new myocardial infarctions (MI), and 320,000 recurrent.  Average age of first attack is 64.5 for men and 70.4 for women.   The lifetime risk of developing CHD after the age of 40 is 49% for men and 32% for women.  CHD in women lags behind men by 10 years and 20 for the more serious evens such as MI and sudden death.  CHD causes 1 in 5 deaths (451,326 in 04).  Of those who experience a coronary attack in a given year, 38% will die during the following 12 months.  Of those who die from CHD, 82% are over the age of 65.  Overall CHD death rates decreased by 59% from 1950 to 1999 (see note at bottom for reason).  Non-sudden CHD death decreased by 64%, and sudden by 49%.  Alabama has the worst death rate fro CHD of 364.2, California is ranked 28th with 276.4, Hawaii 3rd with 230.4, and Minnesota 1st with 211.1.

 

From Wikipedia.org:  About one half the smokers will die of illnesses due to smoking.  A world-wide a billion people this century will die this century from the health consequences of tobacco.  1,205 US citizen a day die from tobacco related illnesses, of which the main forms are diseases of the cardiovascular system.  Incidence of impotence is 85% higher in male smokers.  Lung cancer, which was rare before 1900, will afflict 10% of smokers, yet only 1.33% of non-smokers—of whom half of this number is attributed to second-hand smoke. All forms of cancer are increased by smoking; for example, pancreatic cancer by 250%.  .   

 

For a delightful 1922 brochure by Dr Kellogg (of cereal fame) on tobacco http://healthfully.org/tobacco/id8.html 

 

Big PhARMA claims that it is the drugs which prolong life, but rather it is the reduction in cardiovascular disease, and this is attributed in the main to the reduction in the smoking rate—whose major impact upon the stats takes 20 years.  Smoking reached a high of 59% of the male and 46% percent of the female adult population in the early 50s.  It currently is at 27 & 22% respectively (MORE PROOF THAT WOMEN ARE SMARTER THEN MEN).

 

 

Coronary death rate U.S. 2003

 

Women

 

  AGE  

 

Men 

21

 

0-19

 

23

51

 

20-29

 

110

300

 

30-39

 

889

1,538

 

40-49

 

4,767

3,857

 

50-59

 

11,240

7,989

 

60-69

 

16,117

17,997

 

70-79

 

24,082

49,294

 

80 +

 

32,282

 

Annual death rate from coronary heart disease U.S. is 500,000.  The 10-ounce heart beats 100,000 per day and pumps blood through 60,000 miles of blood vessels.

 

Placing a stent (angioplasty) in artery takes about 30 minutes. 

 

Genetic factor MEF2A codes for a protein that makes up part of the cell’s membrane.  When mutated the risk factor for coronary is over 95%.

 

Other genes are being found, such as apoE4, which is involved in arterial inflammation.  There is a mechanism whereby to deal with arterial inflammation plaque forms in affected areas.  This mechanism is mediated by white blood cells.  Vioxx and all the COX-2 inhibitors except aspirin block the part of this mechanism which switches off the plaque formation. 

 

Sudden death from heart attack, without significant prior symptoms, occurs in 59% of men and 64% of women.  

 

Coronary artery walls are about a millimeter thick and flex about 70 times a minute as the heart pumps.  It is thus tough to get a clear image of how occluded.  An angiography (where a die is injected into the blood vessel, can only show how much blood is flowing through the artery, and not the plaque embedded in the wall.  Computed tomography (CT) scanner (a 3-dimensional x-ray machine) can produce striking images, however, it is too risky, and costly for standard screening. 

 

Risk Factors

 

 

Factor

Results

 

Poor ratio of LDL to HDL

4x

 

Diabetes

4x women

2x men

Hypertension

2x women

3x men

Stress & depression*

3x

3x

Healthy diet

- 30%

 

Abdominal obesity

2x

 

Lack of exercise

+ 20%

 

Smoking long term

2x (1 pack)

 

 

 

 

 

  • Psychological factors do not directly affect the heart, but rather have an impact on lifestyle or for some are associated with increased blood pressure.

 

THE CHOLESTEROL PROCESS:

 

1.        Cholesterol in the bloodstream infiltrates the arterial wall

 

2.        Immune system dispatches macrophages to consume the cholesterol.  The bloated macrophages become foam cells.

 

3.        Foam cells accumulate to become a major component of the plaque. 

 

4.        To keep the arterial walls slick and smooth muscle cells form a cap.

 

5.        Foam cells in the plaque secrete chemicals that weaken the cap.

 

6.        When the cap cracks, plaque seeps into the bloodstream, and can form a clot which can block the flow of blood.

 

7.        Inflammation process is believed to soften the plaque. 

 

 

Those who have a financial interest in the outcome manipulate the results, Major study finds that all 37 journal articles positive effects over stated; the average was 32%. Statins cause erectile dysfunction, cognitive imparement, and cancer.  

Lipitor (2011) lifetime sales $131 billion, tops all drugs.  Plavix at $60 billion is second.

 

STATINS CANCER Link

52% short term

 

LA Times, Health section, July 21, 2008  --  excerpts

Vytorin, the combination drug (simvastatin (better known by its commercial name Zocor) and ezetimibe--known as Zetia) prescribed to lower cholesterol, sustained another blow today, when the author of a major clinical trial announced that the medication had failed to drive down hospitalization and death due to heart failure in patients with narrowing of the aortic valve. In the process, researchers in Norway detected a significant blip in cancers in the 1,800 subjects they followed

Today's findings suggested something more ominous: the incidence of cancer -- and of dying of cancer -- was significantly higher in the patients taking Vytorin. Altogether, 67 patients on placebo developed cancer during the trial. Among subjects on Vytorin, 102 developed cancers of various kinds.*  This is the second adverse press—the first being in March 08, when the ENHANCE trial found that Vytorin fared no better than a placebo at reducing plaque buildup on the walls of patients' arteries.* *

Comments by jk

Simvastatin (Zocor) is off patent.  Thus in a scramble for profits a combination drug (on patent) was introduced.  Direct to consumer market cost $155 in 07—mainly TV ads. 

*  The pressing issue is that since the development  of Statins, the very first animal studies in the 60s it has been known that Statins increase the incidents of cancer.  However, nearly all studies done thereafter have not included cancer. 

*  Several studies have failed to find a reduction in the build of plaque, even thought the statins including Zocor, reduce LDL and cholesterol.  Few studies include the principle reason for taking a statin, namely a reduction in the death rate.  Claims for such reduction probably entail a failure to control the contravening variable, aspirin usage.  Given a pile of evidence, including the very mechanism of plaque formation, which involves inflammation process, I must conclude that the use of statins is highly suspect.  Given the harm done including cognitive impairment, weakness, and cancer, if my skepticism is born out, the harm done by statins as a course of treatment will far surpass that of VIOXX which killed over 200,000 people world wide by accelerating atherosclerosis. 

 EXTENDED RELEASE NIACIN IS A SAFER, AND A MORE EFFECTIVE WAY TO LOWER MI RISK!