RECOMMENDED CANCER, STARVING DIET, MACROPHAGES


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Cancer basics and starving cancer--jk
90% CHEMO SUCKS--BMJ REVIEW, 2016
Starving cancer by fasting and ketogenic diet, a review
Cancer as a metabolic disease, starving cancer--Seyfried, 2014
Highlites of Seyfried 2014 Plus 2 more articles
Ketogenic diet starves cancer, Seyfried Journal 2007
Role of Macrophages in metastatic cancer
Metabolic pathways and cancer growth--2008 review
Glutimate cancer treatments
Glutamine and cancer-2001 review
Blocking Glutimate metabolism by cancer
Ketogenic diet starves cancer, known as Warburg effect, 1924
Otto Warburg's article plus study of Warburg effect
Mega Vitamin C slows cancer invasion, Pauling trial
Mega Vitamin C slows cancer invasion, Pauling trial

Survival is lengthened by strengthen the collagen function of cellular adhesion, thereby slowing down the invasion and spread of the cancer cells.  Colon cancer spreads mainly vegetatively unlike for example small cell lung cancer with early and aggressive metastasis.  Thus colon cancer was a good choice for their clinical trial.  The uncompromised immune system is also important.  If they added large dose (2 gm/day) of aspirin the results would like be even better.  A third adjunct would be hormone replacement therapy, and the most important would be to starve the cancer with fasting and ketogenic diet, since cancer metabolize glucose in a very inefficient anaerobic process which produces 1/15th of the ATP that occurs in aerobic metabolism using the citric acid cycle.  There are journal articles supporting all of these assertions.   Thank you pharma for putting profits before people—the dictates of capitalism.   

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Ewan Cameron and Linus Pauling, Cancer and Vitamin C, Camino Books, Philadelphia 1993, 1979

Probably all malignant tumors liberate an enzyme, hyaluronidase, that causes the glycosaminogycans to be cut into smaller molecules, thus weakening the intercellular cement… another enzyme, collagenase, that causes the collagen fibrils to be split into small molecules.  Cameron and Douglas Torman, on the basis of some chemical arguments [in 1970]. Suggested that an increased concentration of vitamin C in the body would stimulate the normal cells to produce increased amounts of the substance hyaluronidase inhibitor…… Linus Pauling point out that it is known that vitamin C is required for the synthesis of collagen[1]…Pauling suggested that an intake of 10 grams of vitamin C per day be given to the patients with advanced cancer. “ For most improvement becomes apparent between the 5th to 10th day, which may be very transient, or it may be for weeks or months, and in a few patients prolonged and accompanied by such evidence of objective benefit to included permanent regress has been induced,” p. xi-xii. 

 Carcinoma is a malignant tumor that arises from the cells of any covering membrane.  Because such covering surfaces are the first to be exposed to carcinogenic influences, carcinomas account for more than 90% of all malignancies. 

Adenocarcinoma indicates that the tumor has arisen from some glandular structure and has retained some semblance of glandular formation. 

Sarcoma are tumors of the supporting tissues, such as bone, cartilage, muscle,  fibrous tissue, joint surfaces and fat.  They comprise less than 5% of all malignancies.  P. 20

Basal cell, squamous –cell epithelioma, malignant melanoma

And even in the best of hands, the success rate is only about one in five.  One patient might receive some benefit, while the other four have been rendered thoroughly miserable. To no advantage.  And even the one success is usually comparatively short lived, frequently no more than a matter of months in the usual solid cancers… p. 68.

In 9154 and 1959 Dr. W. J. McCormick, a Canadian physician... recognized that the generalized stromal changes of scurvy (changes in the nature of the tissues) are identical with the local stromal changes observed in the immediate vicinity of invading neoplastic cells, and surmised that the nutrient (vitamin C) that is known to be capable of preventing such generalized changes in scurvy might have similar effects in cancer.    The evidence that cancer patients are almost invariable depleted of ascorbate lent support to this view.  P. 101.

Thus a goat the sized of a man (weighing 70 kilograms, 154 pounds) synthesizes 13,000 mg of this vitamin each day.  For other species—mouse, rat, cat dog, cow, squirrel, and even the house fly—the amount synthesized is 2,000 to 20,000 mg per day). The only resemble explanation of the fact that the smaller amounts would lead to poorer health.  

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[1] A similar issue exists for diabetics who through a defect in vitamin C storage are low in certain tissues that store it, and this affects negative the production of collagen and thus is the major cause of the comorbidities associated with diabetes.  For more on this go http://healthfully.org/rt2d/id1.html and subsequent pages in that diabetes section. 

National Academy of Science, September1, 1978,    > vol. 75 no. 9,   > Ewan Cameron,  4538–4542

 

Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer*

1.       Ewan Cameron and Linus Pauling

http://www.pnas.org/content/75/9/4538.short

Abstract

A study has been made of the survival times of 100 terminal cancer patients who were given supplemental ascorbate, usually 10 g/day, as part of their routine management and 1000 matched controls, similar patients who had received the same treatment except for the ascorbate. The two sets of patients were in part the same as those used in our earlier study [Cameron, E. & Pauling, L. (1976) Proc. Natl. Acad. Sci. USA 73, 3685-3689]. Tests confirm that the ascorbate-treated patients and the matched controls are representative subpopulations of the same population of “untreatable” patients. Survival times were measured not only from the date of “untreatability” but also from the precisely known date of first hospital attendance for the cancer that eventually reached the terminal stage. The ascorbate-treated patients were found to have a mean survival time about 300 days greater than that of the controls. Survival times greater than 1 yr after the date of untreatability were observed for 22% of the ascorbate-treated patients and for 0.4% of the controls. The mean survival time of these 22 ascorbate-treated patients is 2.4 yr after reaching the apparently terminal stage; 8 of the ascorbate-treated patients are still alive, with a mean survival time after untreatability of 3.5 yr.

 

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ORIGINAL ARTICLE 1976, update above  -- same title in both

http://www.pnas.org/content/73/10/3685.short

Abstract

Ascorbic acid metabolism is associated with a number of mechanisms known to be involved in host resistance to malignant disease. Cancer patients are significantly depleted of ascorbic acid, and in our opinion this demonstrable biochemical characteristic indicates a substantially increased requirement and utilization of this substance to potentiate these various host resistance factors. The results of a clinical trial are presented in which 100 terminal cancer patients were given supplemental ascorbate as part of their routine management. Their progress is compared to that of 1000 similar patients treated identically, but who received no supplemental ascorbate. The mean survival time is more than 4.2 times as great for the ascorbate subjects (more than 210 days) as for the controls (50 days). Analysis of the survival-time curves indicates that deaths occur for about 90% of the ascorbate-treated patients at one-third the rate for the controls and that the other 10% have a much greater survival time, averaging more than 20 times that for the controls. The results clearly indicate that this simple and safe form of medication is of definite value in the treatment of patients with advanced cancer

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As required by law, I am not recommending that the public do as I do.  I am only setting out why some scientist subscribe to a different theory of cancer and its treatment, and what I would do based on their theory.  See your physician for medical advice.