|
2B Why We are the Sickest
Mammals 8/28/2022
Volume 1 is sections 1 to 3, Volumes 2 contains sections 4 to 6
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SECTION
1: Low
sugar populations:
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6) MTDD CC IR, LR, lipophilia, type 2 diabetes
|
|
1) The sickest of mammals, why?
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SECTION
4: Major
CC for CAWD
|
|
2) LSP biomarkers are better
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1)
Excess of large lipid droplets and NAFLD
|
|
3) Burkitt and Trowel’s CAWD book, historical accounts
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2) Uric acid & urate sensitivity
|
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4) Nature’s biological systems,
a guide
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3)
Collagen issues
|
|
SECTION 2:
Fructose and
unsaturated fatty acids:
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4) Endothelial dysfunction urate crystals,
collagen & UFAs
|
|
1) Basic-on sugars, metabolism, fructation, etc
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5)
Chemicals & drugs CC for MTDD and CAWD
|
|
2)
Fructose receptors in jejunum
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SECTION
5: Western
diet conditions
|
|
3) Fructose
consumption, Gov’s numbers
|
1)
Measurements of risks & CAWD
|
|
4)
Fructose, fructation, ROS causes MTDD, RAGE
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2)
Parkinson’s disease, then-&-now 3) constipation
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5) Polyol
pathway, glucose to fructose in two
steps
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4)
Diabetes, drugs, history, etc.
|
|
6)
Rancid UFAs in membranes promotes MTDD
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5)
Type 2 diabetes and diet, low carbs vs. drugs 5)
|
|
7)
The fat stories, science and history
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6)
Theories of aging
|
|
SECTION
3: About
mitochondria:
|
7)
Conditions associated with MTDD
|
|
1)
MTD structure, metabolism, and repair systems
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SECTION 6:
THE FIXES, what’s good
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2) MTD other functions
|
1)
Autophagy the repair, replace, and recycle systems
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3). Endoplasmic reticulum MTD’s protein factory, etc.
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2) Sex
hormones and other supplements
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4) Defective metabolism of cancer, mtDNA, DNA:
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3) Diet
basics, energy restriction, keto, and fasting diets
|
|
5) MTDD the gateway to CAWD, thyroid dysfunction
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4)
Fixing social environment
|
B-5
fructosylation
and fructose, MTDD, IR, reduced rate of autophagy, reduced
production of ATP CAWD conditions associated with the
western diet, CC contributing
cause, ED
epithelial dysfunction/cells ER endoplasmic
reticulum HSP high sugar
population, IR insulin resistance,
KOL
key opinion leader, LR
Leptin resistance, LSP low
sugar population MTD mitochondria
(/al), MTDD mitochondrial dysfunction, NAFLD
non-alcoholic liver disease, t2d
type two diabetes UFAs unsaturated fatty acids
|
|
Section 1: Low Sugar Populations (LSP):
Chapters: 1. The CAWD book 2. LSP markers are better 3. Burkitt and Trowell’s
CAWD book,
historical accounts 4. On not a science
and on the nature of biological systems
Chapter
1; the CAWD mystery : 1. Two worlds
2. The
mystery 3. A glimpse
at the topics (CAWD book) 4. How
excess sugar causes CAWD 5. Defective
mitochondria 6. CAWD
7.
Where fructose is metabolized 8.
The voyage Good
Chapter
2: LSP biomarkers are better: 1.
LSPs compared to HSPs
biomarkers 2. Wearing the right
glasses, a glimpse of what to come, the difference
Chapter
3: Burkitt & Trowell’s CAWD Book, historical accounts: 1. review of their book and related works
Chapter 4: Nature’s of biological systems,
a guide: 1. Introduction 2.
On JK’s voyage 3. Three categories:
ethics, evidence, education & social bonding 4. Devilish system 5. Evolution keeps us healthy 6. Evolution keeps plants healthy 7. The Bell
Curve Fallacy 8. Social
bonding, regulatory and educational
capture 9. The vista of live
Section 2: Fructose and unsaturated fatty acids (UFA):
Chapters: 1.
Basics on sugar, metabolism and
fructation 2. Fructose receptors
jejunum 3. Fructose consumption, Gov’s
numbers 4. Fructose through fructation
causes MTDD 5. Polyol pathway, glucose
to fructose in 2 steps 6. Rancid UFAs
in membranes promotes MTDD 7. The fats
stories, science and history
Chapter 1: 1. Basic-on
sugars, metabolism, fructation, etc.:
1.
Basic knowledge
2. Metabolism in the cytosol:
glycolysis, fructolysis, pyruvic acid, lactic acid fermentation, amino
acid catabolism, pentose phosphate pathway, glutathione, cAMP (cyclic adenosine
monophosphate), acetyl CoA, phospholipid.
3. Metabolism in the mitochondria: Krebs cycle, lipolysis, fasting
state, beta-oxidation (fat metabolism), ketone bodies, oxidative
phosphorylation (ADP converted to ATP), electron chain transport in the MTD,
superoxides & free radicals 4.
Major sugar facts 5. The Sugars:
sucrose, glucose, galactose, ribose,
sorbitol, glycogen, glycogenolysis, gluconeogenesis 6. Fructose as a poison--basic flow
chart 7. On fructose, 8. Fructose
is
different than glucose 9.
Industries being industries
Chapter
2: Fructose receptors jejunum: 1. Reactive sugars cause
MTDD 2. Location of fructose metabolism 3. Industry’s
response GOOD
Chapter 3: Fructose consumption,
Government’s
numbers: 1. The road to a
health disaster 2.
All sugars with fructose count 3. A
brief history of sugar consumption
4. Hedonic pathway causes sugar
addiction 5. On the obesity
numbers 6. The pathogenic
consequences 7. Fructose causes MTDD,
an introduction 8. The information
systems are marketing
Chapter
4: Fructose fructation, ROS causes MTDD: 1. Introduction fructation
causing MTDD 2. An Overview 3.
mtDNA and IR 4. Fructation causing MTDD, the
evidence 5. Reactive oxygen species
(ROS) a CC for MTDD 6. Milliard reaction, Strecker degradation 7. Advanced glycation end-products (AGEs). 8.
Reactive nitrogen species 9. Lysine deficiency 10. NADPH depletion 11. Some other effects
of fructation of the
MTD 12. Fructose and the kidney
13. Fructation a brief summary 14.
KOLs’
exoneration of fructose 15. A couple
of lessons from the above 16. JK’s
answer to MTDD and fructation of imports
Chapter 5: Polyol
pathway, glucose to fructose in 2 steps: 1. Introduction 2. Osmotic pressure from excess sorbitol and glucose, pharma’s
position 3. Another statement of
Pharma’s theory 4. Hypertonicity
challenged 5. The
polyol pathway and NADH
depletion—possibly 6. Low
ascorbate in diabetics 7. A drug to
block the polyol pathway thus lower sorbitol
8. Stuffed cells turn on de novo
lipogenesis 9. Fructation, urate
crystals, UFAs, B-4and lipid droplets damages the kidneys 10. Why blame
pharma 11. The rat lab, the smell of methylamine--10 issues 12.
Blaming glucose instead of insulin and drugs
12. Blaming glucose instead of insulin resistance
13. Why LSP on high carb diet don’t
through PP
have CAWD 14. Evidence for fructose’s
pathogenic role through PP 15. Fructose
is cleared last from cells and blood
Chapter 7: The fats
stories: science and history: 1. UFAs won the
battle 2. Trust the government, shot
in the foot almost—I missed 3.
Organizations for hire, AHA 4. Fat
compositions 5. Extraction of seed oils
and rancidification 6. In praise of
carbs 7. Glucose is essential for the
brain, or is it? 8. Saturated fats
are toxic, or are they? 9.
Trans-fats are bad, or are they? 10. What are the regulations of
trans-fats? 11. Saturated fats are
good for you 12. Evidence that coconut
and MCT oils stimulate neurotrophins 13
Evidences of toxic compounds in virgin olive oil 14. Other ways to stimulate
neurotrophins 15. What fats are
good 16. A review of palmitic acid and
fructose 17. Communicating with the
public 18. The one two punch, fructose
and UFAs, the road to MTDD and CAWD
Section
3: About mitochondria:
Chapters: 1. MTD structures,
metabolism and repair systems 2. MTD other
functions 3. MTD’s
protein factory, endoplasmic
reticulum 4. Defective metabolism of
cancer, mtDNA, nDNA, and mutations 4.
MTDD, fructose, mtDNA damaged, thyroid dysfunction 5. MTDD CC for IR, LR, lipophilia:
Chapter
1: Mitochondria structures metabolism, and repair
systems: 1. MTD basics 2.
Mitochondria structures and functions
3. External connections, microtubules
4. mtDNA repair systems
5. Fission and fusion 6. Mitophagy
7. Sex hormones are protective 8. ATP, adenosine triphosphate
production 9. MTDD
and under production of ATP.
Chapter
2: MTD other functions: 1.
Regulating processes 2. Synthesizing
molecules 3. Urea cycle 4.
Pregnenolone 5. Heme
6.
iron sulfur cluster 7. Calcium storage and signaling 8. Senescence and
apoptosis
Chapter 3: Endoplasmic
reticulum, ribosomes and MTD: 1. Introduction
2. Descriptions of rough, smooth,
and sarcoplasmic endoplasmic reticulums 3. The ribosome and mitoribosome functions 4. On
the trio: MTD, ERs, and nucleus 5.
The tubules 6. Dysfunctional
ERs, causes 7 . Fructose and
endoplasmic reticulum stress 8. Rancid
membranes in ER 9. Proteins
tagged with sugars. GOOD
Chapter 4: Defective metabolism of cancer, mtDNA nDNA: 1. Historical
background 2. Warburg and the Warburg
effect 3. On starving cancer
4. Golden era of medicine 5 Consequences of mutations 6 Inherited mtDNA mutations 7. Reactive chemical
assault 8. Inherited nDNA mutations INCOMPLETE
Chapter
5: MTDD, the gateway to CAWD, thyroid
dysfunction: 1.
Historical, my standing on the shoulders, 2. Briefly on IR, t2d, and MTDD
3. The assault upon mtDNA 4. The vulnerable mtDNA criticized
by KOLs 5. The repair systems fails &
tables 6. What is causing MTDD
7. How fructose causes MTDD in more than
the liver 8. Rancid fats in MTD membranes 9.
Thyroid a CC for CAWD 10.
Thyroid dysfunction is a CC for fatigue and t2d 11. NAFLD CC for CAWD NEED To put all the NAFLD into doc and organize
if for here. NEED to cover less of ROS
& like it is in 2:4, Milliard reaction
Chapter
6: MTDD CC for IR, LR, lipophilia, CAWD : 1. Introduction 2. Insulin resistance and cellular
glucose
stuffing 3. MTDD and other
CCS for IR 4. The
road to IR through the liver 5. Insulin
functions 6. Excess insulin, a marker
for health problems 7. Leptin
functions 8. Some comments on leptin’s
functions 9. Weight regulatory system
causes obesity 10. More on weight-regulatory
system 11. CAWD
Section 4: More
major contributing causes for CAWD:
Chapters: 1.
Excess of large lipid
droplets excess and NAFLD 2. Uric Acid
& urate sensitivity 3.
Collagen issues 4. Endothelial
dysfunction, CC uric acid, collagen and UFAs
5. Chemical CC for MTDD and CAWD
Chapter 1: Excess of large lipid droplets and NAFLD: 1. Introduction
to lipid droplets (LD) and
fats 2. On why fats are the preferred stored energy
molecule 3. On large lipid
droplets 4. The adipose tissue
alternative to LD 5. Major differences
between lipid droplets and adipose tissue
6. NAFLD 7. Lipophilia,
NASH, fatty kidney, and fatty pancreas 8.
The fasting cure, bariatric surgery and water fasting 9.
The role of adipocytes 10. Lipotoxicity 11. T2d,
extreme IR, LD, & beta cell burnout
12. Asleep at the wheel
Chapter 2: Uric
Acid & urate sensitivity: 1. Introduction 2. Purine family of compounds 3. Urates and uric acid 4. KOL’s
version of hyperuricemia 5. Hyperuricemia and fructose 6. Loss of uricase gene in big-brain
primates 7. Urase and bacteria
8. Gout, hyperuricemia, and micro
monosodium urate crystals 9. A bit of
research history 10. Monosodium
urate and neuropathy 11. Monosodium urate crystals and myocardial
infarction 12 A stab at the process,
encapsulation 13. What
I would do if I had gout or
hyperuricemia 14. Hyperuricemia
and uric acid’s other
consequences 15.
Uric acid good side
Chapter 3:
Collagen issues: 1. Collagen basics 2. B-4 and the
reduced collagen replacement . 3. Low ascorbate and collagen cross
links (and Pauling-cancer footnote—develop in 3:3). 4.
Low ascorbate in the polyol pathway 5.
Ignoring the
obvious, ascorbate 6. Insulin and
insulin like growth affect upon collagen
7. Stem cells and autophagy in
collagen production 8. Collagen in
endothelial dysfunction and cardiovascular disease 9. Collagen and hemorrhage
and ischemic
strokes 10 Collagen and
bone and cartilage issues 11. Endogenous antioxidants
Chapter
4: Endothelial dysfunction, CCs urate
crystals, collagen, and UFAs: 1. Endothelium and
endothelium cells 2. Endothelium
dysfunction(ED) 3. Uric acid and
urate crystals damage endothelial cells
4. Endothelial dysfunction, a CC for cardiovascular disease 5.
Nephropathy 6. Collagen, IR, ascorbate, and ED 7. Rancid fats and ED
Chapter 5:
Chemicals and drugs CC for MTDD and CAWD: 1. Introduction 2.
Sensitivity to chemicals 3.
Mitochondrial link 4. How chemicals
damage the MTD 5. Lectin and natural poisons
6. MTDD conditions
7. Markers
associated with MTDD
8. Measurements
of MTD functions in Vivo 9. Bell curve fallacy 10. List of drugs which cause MTD damage 11. Hall of
shame: a) COX-2,Vioxx &
Celebrex, b) Statins c)
Anti-arrhythmia drugs, d) adult diabetes
mellitus,
e) neuroleptics 12.
The one, two three punches 13. What have we learnt? 15. Scientists and physicians for hire and
mass delusion 15. The neuroleptic coffin nails good
Section 5: Western
diet conditions:
Chapters 1.
Measurement
of risks & CAWD, 2. Parkinson’s disease,
then & now 3. Laxatives and
chronic constipation 4. Conditions
associated with MTDD 5). General theories of
aging
Chapter 1: Measurements
of
risks:
1. Introduction 2 Biomarkers
LSPs compared to HSPs 3. Measurement
of mitochondrial size and functions
4.Receptors for advanced glycation endproducts, RAGE and AGE 5.
My RAGE against glucose toxicity 8. Drugs that contribute
to CAWD 7.
Why seniors get most of the age-related conditions. 8. The
CAWD list
Chapter 2:
Parkinson’s disease, then & now: 1. Introduction 2 Summary
of current treatment, 3.
Dr. Bill’s developing Parkinson’s disease psychosis: 4. On
pharma being pharma, PD example 5.
A bad model on the need for dopamine 6. On Dr. Bill’s
at-home-care 7.
Researching Parkinson’s disease
8. Bill’s progress
9. Parkinson disease and the neurotransmitters 10. The brain
and Parkinson’s disease 11. Bill drug cocktail 12. A 100-years of textbooks on PD 13. Guideline
standards 14. CAWD and the MTDD again for PD
15. why the Alzheimer’s disease
pandemic:
Chapter
3 Laxatives and chronic constipation: 1.
Structures of laxatives for chronic
constipation 2. Constipation, bowel
movement, should be daily 3. Associate’s
chronic constipation 4. The
search
5. On common alcohol sugars
6. On the sugar laxatives choices
7. Other laxatives 8. Plant laxatives 9 Enema
10. Regulatory history
Chapter 4: Diabetes pandemic & its natural cure:
1.
The t2d numbers and the crapolla 2.
What is diabetes mellitus? 3.
Introduction 4. Normal is not good
enough 5. Dr. Kraft use of the insulin
tolerance test 6. The tidal wave of
diabetes mellitus 7. Early
western history of diabetes 8. Diabetes
care before the drugs for t2d 9.
The diet in the pre-drugs for t2d era 10.
Dietary low-carb management of t2d, Merck
1950-61 11. Diet management
of t2d, and the undiagnosed
t2d 12. Low carb diet for diabetes
mellitus 13. NAFLD
to IR and fatty pancreas leads to t2d 14. Bariatric surgery cures
t2d 15. Health benefits of bariatric surgery
and fasting 16. Curing t2d with ketogenic
diet and fasting 17. Supplements and
exercise good
Chapter 5: Diabetes, medication history, etc. 1. Introduction 2.
On why t2d is a progressive disease
3.
Treating the sign, glucotoxicity, instead of the cause IR 4. Glucotoxicity
and hyperosmolar 5. the pancreas and extraction of insulin 6.
Elliot Joslin and his switch to 30%
carbohydrates 7. Why diabetic ketoacidosis (DKA) isn’t caused
by fats,
ketones, or low serum pH: 8. Historical view of t2d, Joslin, Keys, Sugar Association
and the lipid hypothesis 9. Historical drug sulfonylurea 10.
Metformin, wonder drug? 11. Hypoglycemia
and lactic acidosis connection 12.
Other diabetic medications 13.
The ADA 2019 guidelines 14
Population studies 15. Weight, diabetes, and CAWD 16. What caused the children with t1d in
pre-insulin days to waste? 17. What’s
causing t1d (a speculation) 18. Bad
diet advices 19.
Conflating the 2 very different type of diabetes in murine research 20.
Murines produce vitamin C. good
Chapter 6:
Conditions caused by MTDD: 1.
introduction 2. The link to sugar and MTDD
3. Neurodegenerative
diseases and brain metabolism 4. Amyloid
plaque 5. Drugs that are a CC for MTDD
and CAWD
Chapter 7: Theories
of
aging: 1. Introduction. 2.
Caloric restriction 3.
Genes 4. Cell
aging regulatory system (CAR) 5. The MTD theory of aging and the role
of
the western diet 6. Free Radical
theory of aging 7. General theory of
aging
Section 6: The Fixes, what’s good:
Chapters 1. Autophagy and the
repair, replace, and recycle systems 2.
Sex hormone fine tune autophagy, other supplements 3. Diet basics energy
restriction, keto and
fasting diets 4. Diabetes history and
diet 5. Diabetes, drugs, history, etc. 6.
Fixing social environment
Chapter 1: Autophagy the
repair, replace, and recycle system: 1. introduction 2. Structure and processes of autophagy:
organelle, mitochondria associated membranes (MAM), lysosome, phagosome, Golgi
apparatus, autophagosome, macroautophagy, microautophagy, chaperone-mediated
autophagy (CMA), mitophagy, lipophagy, xenophagy, peroxisome, endosome, 3. Stem
cells 4. Apoptosis 5.
Necroptosis in response to pathogens 6. Autophagy’s role in cancer
suppression 7. Apoptosis
turning it up with natural supplements 8. Long-term water fasting
and apoptosis, Barbieri’s 382-day fast
9. AMPK 10. Switches, mTOR and
insulin, pericy 11. Drug fixes?
12. Autophagic lessons & aging
Chapter
2: Sex hormones fine tune autophagy,
other supplements: 1. Sex hormone connection 2.
InCHIANTI longevity study 3.
Sex hormones benefits 4.
Estradiol and testosterone protect
MTD 5. Testosterone and
neurosteroids 6. Estradiol HRT is healthful 7. HERS, WHI, horse estrogen and MPA 8.
Osteoporosis, estradiol with
progesterone fix 9. Epidemic of osteoporosis
and osteoarthritis 10. My historical
note on hormones 11. Why menopause and
andropause? 12. DHEA and DHEAS
introduction 13. DHEA turns on
autophagy 14. DHEA neurosteroids
15. IGF-1 and InCHIANTI Study 16.
IGF-1 autophagy, and CC for MTDD 17.
Pregnenolone a major neurosteroids 18.
Progesterone and progesterin 19.
Neurosteroids summary 20. Brain derived
neurotropic factor (BDNF) 21. Melatonin
22Testosterone, estradiol, and type-2
diabetes 23. My
historical note on hormones 24. Some
supplements, exercise, QALY 25. What to
do for the MTD? 26. Some good pharma
drugs
Chapter 3: Diet Basics:
energy restriction, keto and fasting diets: 1. Mediterranean diet 2. Why
the Mediterranean diet works 3. Weight regulatory system and Tbe
Biggest Loser 4. Blaming the
victims 5 Three types of diets:
caloric energy restriction, low carbs, and Atkins-keto diet 6. How bariatric
surgery causes permanent
weight loss 7. Going without food,
fasting 8. Extended water
fasting—Angus Barbieri record 9. Amino
acids and insulin 10. A modern
update 11. Ketogenic diet
12. A listing of what is best for dieting
for weight loss, managing diabetes, and lowering risk for CAWD (in approximate
order of importance) 13. Personal
note, how I ate the western diet and
escaped 14. Fixing the cause.
Chapter 4: Fixing social environment: 1. Social conditioning, marketing
2. Help from the financial sector
3. The
longevity miracle 4. Political lap dogs 5. Social conditioning and the brain
6.
Prudent behavior
STYLE: address (2:6)
section, chapter #3, item in
chapter. Calibri: inserts
under illustrations; in Sections
are bold and brick red Lucida San: Chapters
2-4-blue 14 pica.
Lucida sans Items in chapters; Sections in
blue time
Roman: footnote Green for lack
of evidence or I missed it
Good is checked
subjects with article, and spacing of titles,
plus key points
Psychiatric section
4 chapter 5 from the Hall of shame section of chapter naming 5
horrific drug families 1 Intro
2 Psychiatric drugs as sedatives, consequences reduced boredom, CAWD,
dementia 3 recreational sedatives,
sedatives for non-psychiatric uses 4
non-psychiatric drugs that cause sedation
5 fog promoted conditions 6
Theory of chemical imbalance 7 Breaking
blind 87% 8 Inert placebo bias
Citalopram KOLs trial bias 10 about citalopram 12 Hamilton Scale, many ways to assure improvement
13 FDA accepts 2 trials and ignored the
negative 5 14 Citalopram 4-6 week
trials, no mention of 5 others 15 85%
benefited claim 16 Gotzsche on
STAR*D description & results
17 Gotzsche attacks 18 Doctors resistant to helping patients quit 19 withdrawal syndrome 20
Wiki’s KOLs missed symptoms 21
Tardive dyskinesia split 20 ways 22
Terminal acts (TA) suicide/murders sedatives as CC 23 Why
are TA much more common than in the 50s? sedatives 24 5
categories of causes: neurotransmitter
imbalance, chemical lobotomy, cognitive decline, withdrawal syndrome & dopamine
reduction 23 sedatives cause TA
25 neurotransmitters 26 chemical lobotomy 27 Alzheimer’s disease, diminished
housekeeping 28 reduced brain size and
poor functioning 29 dopamine
30 Dopamine reduction promotes TA 31 cognitive decline & other 4
categories
promote TA 32 Greater the
dose and longer the increased
chance for TA, also extreme withdrawal agitation 33 Dopamine’s role
stated again 34 genes CYP450 the
complexity of the brain, 200 chemical
messengers
Volume I
Section 1: Low Sugar Populations (LSP): 8/31/22
Chapters: 1. The CAWD book 2. LSP markers are better 3. Burkitt and Trowell’s
CAWD book,
historical accounts 4. Nature’s
biological systems guide
Chapter
1; The CAWD mystery: 1. On my beliefs concerning
medical science 2. Two worlds
3. The putative longevity miracle 4. The book and my voyage
5. The mystery
6. A map of sections 7. On JK and style
Chapter
2: Diseases of the Western diet: 1. Introduction
2. Why we got the wrong a 3. The
historical evidence and beliefs on sugar and carbs affecting health 4.
The literature on conditions of
affluence 5. Books on conditions of
affluence 6 The authors of the seminal
work on CAWD 7. Seminal book, Western Diseases: Their Emergence and Prevention
8. The
reception, a review
Chapter
3: LSP biomarkers are better: 1. Introduction
2. Biomarkers the Kitavans 3. The mitochondrial line 4. Other paleo populations
5. On Paleo diet 6 The mitochondrial
theory. why we are the
sickest of mammals 7. The diet for IR
peoples
Chapter
4: Nature’s
biological systems, a guide:
1. Introduction 2. Three categories: corporate ethics, evidence base,
education & social bonding 3. Devilish system 4.
Evolution keeps us healthy 5. Evolution keeps plants healthy 6.
The Bell Curve Fallacy 7. Social
bonding, regulatory and evidence capture
8. On JK’s voyage
Section 2: Fructose, its metabolism, and
unsaturated fatty acids:
Chapters: 1.
Basics on sugar, metabolism and
fructation 2.
Fructose receptors jejunum 3. EW4S.
Fructose consumption, Government’s numbers
4. Fructose through fructation causes MTDD 5. Polyol pathway,
glucose to fructose in 2
steps 6. Rancid UFAs in membranes, MTDD,
and CAWD 7. The fats stories,
science, and history
Chapter 1: 1. Basic-on
sugars, metabolism, fructation, etc.:
1. Major sugar facts 2.
All about fructose 3. On sugars, fats, metabolism
4. Briefly insulin resistance 5. Historical note on the Sugar
Association, the Yudkin case 6. Know the villain
Chapter
2: Fructose receptors jejunum:
1. Reactive sugars cause MTDD 2. Location of fructose metabolism
3. Industry’s response
Chapter 3: Fructose
consumption, Government’s numbers: 1.
The road to a health disaster
2. All sugars with fructose count
3.
fructan 4. A brief history of
sugar consumption 5. Hedonic
pathway causes sugar addiction 6.
On
the obesity numbers 7. The pathogenic
consequences 8. Fructose causes MTDD,
an introduction 9. The
information systems are marketing checked
Chapter 4: Fructose, fructation, ROS, causes, MTDD, RAGE: 1.
Introduction fructation 2. An
Overview 3. Methylglyoxal,
dicarbonyls the Trojan horses 4. RAGE
5. mtDNA and IR, a review of key points 6. Reactive oxygen
species (ROS) a CC for
MTDD 7. Milliard
reaction, Strecker degradation 8.
Advanced glycation end-products (AGEs) and their receptors (RAGE) 9. Reactive nitrogen species
10. Lysine deficiency 11. NADPH depletion 11. Some other effects of fructation of the
MTD 13. Fructose and the kidney
14. Fructation a brief summary 6. Fructation causing
MTDD, the evidence 15. KOLs’
exoneration of fructose, 16 examples 16.
A couple of lessons
Chapter 5: Polyol
pathway, glucose to fructose in 2 steps: 1. Introduction 2. pharma’s position osmotic pressure
from
excess sorbitol and glucose
3. Sorbitol hypertonicity challenged 4. The polyol pathway
and NADH
depletion—possibly 5. Low
ascorbate in diabetics 6. A drug to block the polyol pathway
thus lower sorbitol 7. Stuffed cells
turn on
de novo lipogenesis 8. Fructation, fatty
kidneys urate crystals 9. The rat lab,
the smell of methylamine (12 issues) 10.
Evidence for fructose’s pathogenic
role through PP 11. Fructose is cleared
last from cells and blood
Chapter
7: The fats stories: science and
history: 1. UFAs won the battle
2. Trust the government, shot in the foot almost 3. Organizations
for hire, AHA 4. Fat compositions 5.
Extraction of seed oils and rancidification 6. Saturated fats are toxic, or are they?
7 Trans fats are bad, or are they? 8. What are the regulations
of
trans-fats? 9. Saturated fats are good
for you 10. Evidence
that coconut and MCT oils stimulate
neurotrophins 11. What fats are good?
Chapter
8: on metabolism of sugars, and focus on fructose: 1. Catabolism in the cytosol
2. Metabolism in the mitochondria
3. Points of interest
4. The sugars 5. Fructose as poison
6. On fructose 7. Fructose is different than glucose 8. Industry being industry
Section
3: About mitochondria:
Chapters: 1. MTD structures,
metabolism, and repair systems 2. MTD other
functions 3. MTD’s
protein factory, endoplasmic
reticulum 4. Defective metabolism
of cancer, mtDNA, nDNA,
and mutations 5. MTDD, fructose, mtDNA
damaged, thyroid dysfunction 6. MTDD CC for
IR, LR, lipophilia:
Chapter
1: Mitochondria structures metabolism, and repair
systems: 1. MTD basics 2. Evolution from bacteria
to eukaryotes
3. Mitochondria structures and functions 4. External connections,
microtubules 5.
mtDNA repair systems 6.
Fission and fusion 7. Mitophagy 8. Sex
hormones are protective 9.
ATP, adenosine triphosphate production 10.
MTDD and under production of ATP
Chapter
2: MTD other functions: 1.
Regulatory processes 2. Synthesizing
molecules 3. Urea cycle 4.
Pregnenolone 5. Heme
6. iron sulfur cluster 7.
Calcium storage and signaling 8. Senescence and apoptosis
Ch Chapter 3: Endoplasmic
reticulum, ribosomes, and MTD: 1. Introduction
2. Descriptions of rough, smooth endoplasmic reticulums 3.
Fructose and the endoplasmic reticulum’s
stress 4. The ribosome and mitoribosome
connection 5. On the trio: MTD, ERs,
and nucleus 6. The
tubules 7. Dysfunctional
ERs, causes and conditions 8. Glycoproteins, fructose and
endoplasmic reticulum stress
9. Rancid membranes
in the ER 10. mtDNA protective mechanisms
fail for HSPs
Chapter
4: Defective
metabolism of cancer, mtDNA nDNA: 1. Historical background
2. Warburg and the Warburg effect 3. On starving cancer 4. Golden era of medicine 5. Consequences of mutations
6 Inherited mtDNA mutations 7. Reactive chemical assault 8.
Inherited nDNA mutations
Chapter
5: MTDD, the gateway to CAWD:
1. Briefly on IR, t2d, and
MTDD 2. The assault upon mtDNA
3. The vulnerable mtDNA criticized by KOLs
and rebuttal 4. The repair
systems fails & tables 5. What is causing MTDD 7. How fructose causes MTDD in more than
the liver 8. Rancid fats
in MTD membranes 9. Causes for hypothyroidism 10. Thyroid a contributing cause 11. Thyroid
dysfunction is a CC for fatigue
and t2d
Chapter 6: MTDD CC for IR, LR, lipophilia, CAWD: 1. Introduction 2. Insulin resistance and
cellular glucose
stuffing 3. MTDD, CCs for IR and
MeS 4. Homeostasis 5. Insulin functions
6. The Whitehall Studies 8. Leptin dietary functions 9.
Leptin non-dietary functions 10. Weight regulatory system causes
obesity 11. More on the
weight-regulatory system 12. MTDD a
major CC of IR 13. Behavior that
promotes weight loss
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