the major contributing cause for fatty liver and insulin resistance, and their major
downstream effects including metabolic syndrome, endothelial dysfunction,
excess lipid droplets, hyperuricemia, diminished production of ATP, reduction
in autophagy, and affects upon collagen.
The hemostatic processes depend on ATP; they are functioning
significantly below evolutionary design.
I have used journal articles on each topic to support the modus operandi
for each of the major pieces that explain the pandemic CAWD which is much
more than diabesity and metabolic syndrome. I have over 3,000 references to
journal articles, books and Wikipedia articles supporting the processes
contributing to CAWD and exposing industry’s
tobacco science. The book is divided into 6 sections.
Section 1 is on why
those who eat a low sugar diet
(including paleo peoples) don’t get CAWD, the conditions of
affluence. Burkitt and Trowell’s
1981 survey of populations lacking CAWD is a collection of 27 articles by 34 contributors
who responded to their request for articles on their region’s health issues.
Each country was on their traditional diet,
which lacked refined carbohydrates.
Burkitt and Trowell, and many before them, believed that refined carbs were
the main cause for conditions of
Gary Taubes, in The Case Against
Sugar (2016) Chapter 2 and in Good
Calories, Bad Calories (2008) Chapter
5, covers that topic using additional sources.
Looking into this lead by Taubes, I have added a chapter on the
biomarkers of the paleo peoples—hope to find in English other populations on a
low sugar diet.
provided major insights into the role of diet in diseases, and develops some of
the pathogenic consequences of fructose: its role in NAFLD, hyperuricemia, glycation,
insulin resistance. I have widened the search,
see Section 3. I start with how fructose
is a slow acting poison similar to ethanol.
Section 2 is
on the cause, the science which shows that the reactive sugar fructose is a slow
poison like ethanol (a comparison made by
Prof. Robert Lustig of UCSF). Fructose
is a NET 15-20 times more reactive than the
glucose which is metabolized before fructose. Our consumption of fructose
is beyond what
our repair systems can handle. I go
beyond association to show how fructosylation (the non-enzymatic bonding)
damages the mitochondria. The road to CAWD
starts in the liver where most of the fructose is metabolized. I use
the journal articles to explain how fructose causes insulin resistance first in
the liver and then in most other tissues.
Section 3 is
on mitochondrial and its dysfunction;
which is the major cause for CAWD.
Lustig, Taubes, and others stop with fructose
damaging the liver and causing insulin resistance, diabetes, obesity, NAFLD
(non-alcoholic fatty liver disease); viz., metabolic syndrome. They haven’t
figured out how fructose
enters the mitochondria. In the cytosol, a small percentage of fructose bonds
to proteins and polyunsaturated fats of which some are transported into the mitochondria
where the bonded fructose is converted into very reactive compounds. The damage
to the mitochondria and its mtDNA
causes a reduction in the production of ATP and also the release of reactive
oxygen species which cause more damage in the mitochondria. Covered here is
the chemical reactions &
other evidence leading to insulin resistance, NAFLD, weight gain, Warburg
effect, lipid droplets, etc.
Section 4 is on
those major consequences: built upon
Section 3, MTDD and connected to Section 1: its conditions associated
with western diet, conditions that are rare to very rare among low-sugar
populations. What are the major causes,
to which I found strong evidence for elevated uric acid and the release of the
sharp monosodium urate crystals, collagen
issues, endothelial dysfunction, and diminished autophagy. Add to these major
factors her chemicals
including drugs and polyunsaturated fatty acid which become rancid in cell membranes. All these stresses in an additive way to overload
the repair systems (autophagy); the result is CAWD. The rate of cellular
repair (grouped as autophagy) is
slowed by the reduced production of ATP by the
mitochondria, and by insulin resistance:
insulin turns off autophagy.
Section 5 is on
the conditions: dementia, heart
attacks, cancer diabetes, obesity, osteoporosis, arthritis, atherosclerosis,
strokes, MI, and so on--the CAWD. All
these conditions are rare among
wild-mammals including elephants (long lived) and elderly paleo peoples.
is on the fixes. Chapters are on autophagy, steroids and
neurosteroids, diet basics, diet for diabetics, and last how the media and
schools over-ride the rational module of the brain through social conditioning to
produce the behaviors their sponsors want, including pill pushing, pill popping,
a high-carb manufactured food diet. and unregulated medical industry. As
Prof. Marcia Angell said, pharma is not in the business of education
(referring to CME classes & the media).
putting together a tome with over 3,000 journal references to weave a cogent
fabric from the mounds of evidence to explain CAWD. I have completed in rough
draft form 27
chapters, another 6 have yet to be developed.
Six of the chapters and an outline of all the chapters are posted http://healthfully.org/rbook/. I
would like to share with you my work. Feel
free to make use of my efforts as you see fit.
As Prof. Ben Goldacre (of AllTrials) writes,
We are all in it together (referring
to the broken evidence base and its consequences). We stand on the shoulders
weal has been dashed upon the financial ground by two trillion-dollar gorillas,
pharma and food manufacturers. Our 1950
per-person cost for health care was $750
–in 2009 dollars-- per year to $8,100 in 2009.
What have we got but hype: after
dropping out from the figures the use of tobacco and infant deaths, our life
expectancy is less now than in 1950 and infirmity has risen to an average of 16
years. But there is hope,
I have come to believe
that the financial sector, pursuing greater profits, is working behind the
scene to reduce health costs. Their support
of AllTrials and topics raised by the media is evidence. Let us be counted as
part of the fix.
advice, critical suggestion, support, and response would be appreciated. It
is not about me/us, but about being counted
in making this a healthier world.
I may be reached at
760-542-6676, Benthamite firstname.lastname@example.org. Yes,
I am a utilitarian.
academic background is at http://healthfully.org/rg/id1.html and
my link to the best of documentaries and
lectures on YouTube, each with a rating and description is at /rg/id4.htm and
id12 --over 500 on health related topics.
for your time.
PS: I will be working next on a nontechnical book. It is to be similar to Gary Taubes The
Case Against Sugar (2016) develop from Good Calories, Bad Calories (2008).