Letter on book project sharing

Dear Sir: 6/3 /2022 Why we are the sickest of mammals, the unified theory of illness.

I have solved the mystery why populations on the western high sugar diet get conditions that low sugar very rarely get. I use journal articles to weave the pathogenic processes caused by the reactive sugar fructose. Fructose causes mitochondrial dysfunction (MTDD) by glycation of proteins and unsaturated fatty acids that are transported into the mitochondria (MTD) from the endoplasmic reticulums. MTDD lowers the production of ATP, about 30%.

When sugar became inexpensive the conditions of affluence, became conditions of civilization; then in the 1981 it became Conditions Associated with the Western Diet (CAWD). [1] I need your help to prevent the blizzard of industry-funded science and the beliefs it generates from burying the book.

I want to share with you--in just 4-pages a summary of what I have uncovered from 7-years of full-time research. I build upon what you and others have found. The book has over 2,000 references with about 5% quoted. The evidence is pieced together into a fabric. 1) why CAWD is rare among elderly paleo peoples and others on a low-sugar diet. 2) consequences of the reactive sugar fructose and rancid fats by glycation cause MTDD; 3) MTDD reduces the metabolism of pyruvate. 4) this cause high blood glucose and thus release of more insulin. 5) cells become overstuffed with glucose. 6) stuffed cells to reduce osmotic pressure turn on the polyol pathway which in 2 steps produces fructose, thus more glycation. 7) reduced production of ATP effects every system in the body. 8) the rate self-healing autophagy declines. 9), large lipid droplets, issues with collagen, uric acid, endothelia dysfunction, and 3 major others all are major contributing causes to CAWD.

The list of common age-related conditions is long, but absent for those on a traditional low-sugar diet. The road to this pandemic starts with a yearly average of over 150 pounds of sugar—all sources, includes fruits and fruit juices. Half consume more sugar. With an average of 20% of calories from sugars, the repair systems are overwhelmed. Fructose in the open chain structure longer than glucose, thus is 7-10-times more reactive and the carbonyl and methylglyoxal glycation are hundreds of times more reactive than the sugars—the smoking guns.

After figuring out that fructose damages the MTD in 2016, I started placing the evidence on my website, healthfully.org/rmb and /rlsp. The website, started in 2004, is encyclopedic, thus CAWD is just one topic. Then I realized in early 2018 that a book would have more influence. To be dispositive, the book is technical. I enjoying searching for the best evidence-based answers-- a skill gained though 11 years of attending universities. This hobby of searching for answers is published on my 3 websites. As of this April the work on CAWD, (about over 800 pages). I am publishing it in 2 volumes. The first volume is enclosed. The second needs editing, and both need critical feedback.

Seven sample chapters are posted at /rbook. They are from the 6 Sections in the 2 books: 1, Low Sugar Populations; 2, Fructose a Slow Poison Like Ethanol; 3, Mitochondrial Dysfunction, 4, Major Contributing Causes to CAWD; 5, Western Conditions; 6, The Fixes.

[1] Dennis Burkitt (of Burkitt’s lymphoma) and H.C. Trowell in the seminal survey book , Western Diseases: their emergence and prevention (1981), noticed that conditions of civilization implied that Orientals weren’t civilized, thus their change to western. Their book is a health survey of the populations that didn’t eat refined carbohydrates, which they thought caused CAWD.

Section 1 is on the low-sugar populations (including paleo peoples); they don’t get conditions of affluence (CAWD). I start with our health disaster, then the biomarkers of the paleo peoples., followed by Burkitt and Trowell’s 1981 seminal survey book of populations lacking CAWD. It is a collection of 27 articles by 34 contributors who responded to their request for an article on their region when their population where on their traditional diet lacking refined carbohydrates. Fructose until about 2006 was widely held to be the same as its isomer glucose. Burkitt and Trowell, and many before them, and after, believed that refined carbs were the main cause for CAWD.

Section 2 is on fructose as a slow poison like ethanol. Fructose is over a 100 times more reactive than the glucose because of its longer period of not being in the ring structures and because of its conversion to reactive chemicals. When there is sufficient ATP, liver cells turn on the pathways to make glycogen, uric acid, and palmitic fatty acid. Eventually, the accumulation of lipid droplets in the hepatocytes cause insulin resistance, etc. as described above. Insulin resistance down-regulates autophagy and effects other insulin sensitive systems, some are major causes for CAWD.

Section 3 is on mitochondrial functions and its dysfunction. Dr Robert Lustig, Gary Taubes, and others stopped with fructose damaging the liver and causing insulin resistance, diabetes, obesity, and NAFLD; viz., metabolic syndrome. Fructose on entering a cell is phosphorylated and then converted to pyruvate which is transported into the MTD for the production of ATP as describe above in 1 through 9. Lustig et al assumed that MTD lacking GLUT transporters couldn’t be damaged by sugars--I too was stumped for 8 months. Because the MTD has only 37 chromosomes that code for 13 proteins 95% of MTD proteins are made in the rough endoplasmic reticulum (ER). In the ER a small percentage of fructose bonds to proteins and the smooth ER to unsaturated fatty acids that are transported into the MTD. Bonded to them, fructose forms methylyglyoxal, and dicarbonyls; they are the Trojan horses. In a vicious cycle started by the horses, they cause an increased release of reactive oxygen and nitrogen species in the MTD, etc. Insulin is involved in at least 16 regulatory systems including leptin and autophagy. Leptin affects metabolism & weight. Heme production and calcium storage occur in the MTD; thus, MTDD affects calcium signal and other functions. Apoptosis is initiated through MTD signaling to remove damaged cells. There is a chain from excess fructose to MTDD, to insulin resistance, and then other systems dysfunctions.

Section 4 (2^nd volume) is on major contributing causes for CAWD. Seniors because of the natural decline in ATP are the most ill. Major downstream contributors to CAWD: delayed collagen replacement and mis-folding, endothelial dysfunction, insulin resistance, excess of large lipid droplets, diminished autophagy, monosodium urate crystals, and the environmental pernicious chemicals including many drugs. All these major stresses function in an additive ways; e.g., excess lipid droplet hinder the kidneys, liver, and pancreas; delayed replacement of the collagens affects many types of cells, reduces autophagy causes accumulation of alpha synuclein, tau and beta amyloid proteins in the brain, etc. We are now the sickest of mammals.

Section 5 is on 2conditions caused by MTDD: dementia and diabetes as examples for the reminder of CAWD. All CAWD are rare among wild-mammals including elephants (long lived), elderly paleo peoples, and Orientals who continue to eat their traditional low-sugar, carbohydrate-rich diets. A chapter is on theories of aging based on what has been covered in the books.

Section 6 is on the fixes; what is good: on turning up autophagy, steroids, neurosteroids, diet basics, diet for diabetics, and social shaping which creates the market for the high-sugar diet and pernicious drugs. Humans are a social animal and complex techniques of shaping behavior promotes profits without externalities. The western diet is the main cause for an average 16.7 years of infirmities UK (BMJ article 2019). Profits before people ought not be permitted.

There are a couple of books on MTDD causing CAWD, but they haven’t connected fructosylation in the rough endoplasmic reticulum or the major causes in Section 4. Hopefully, I can share the insights with you and 6 years of gathered evidence. It is not about me, but about the good you can do and the support you can generate. If too off your radar, you could always pass this topic on to an associate or a graduate student. Too many good articles and books have been buried by KOLs and their sponsors: they frame the topics. I wish to help you get health science onto the right foundation. This evidence here would rewrite the causal foundation for the conditions of affluence. Billions of people would benefit with this foundation and a system that put people before profits. We will get a rough ride as Otto Warburg and Linus Pauling have; let us try.