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Book on fructose, mitochondria, and the sickest of mammals

Excess fructose is a slow poison that causes mitochondrial dysfunction.  It poisons nearly very cell in the body (reduces their rates of the production of ATP).  This down regulates most cellular functions, for which some increase the risk for major conditions.  Fructose (one half of sucrose) is a NET 15 times more reactive than glucose.  We consume over 10 times the amount of sugar than our paleo ancestors averaged (15 grams daily).  Wild fruits were small, seasonal,  and had much less sugar than our commercial varieties.   

This book is divided in 6 sections: 1)  Low sugar populations    2) Fructose slow poison    3) Mitochondrial dysfunctions    4) Major contributing cases for conditions associated with the Western Diet    5) The conditions    6)  The fixes and what is good

Most researchers stop with insulin resistance:  the excess insulin as causing the dysregulation of cellular systems.  This book explains how fructose causes mitochondrial dysfunctions, and then goes on to explain the major pathogenic consequences including insulin resistance.

I have yet to find an article or book that goes from fructose to mitochondrial dysfunction, to cellular consequence, and also deal with the fact that low sugar consuming populations rarely get what has been called "conditions of affluence" and more recently called "conditions associated with the western diet"  


This is a technical work, because the evidence confirms the theory as to how fructose and mitochondrial dysfunction causes so many conditions, and because in my search of the technical literature I was able to piece together of the MAJOR pathogenic process. 

Sadly, industry is and has been functioning through scientists for hire to protect their financial gains, through what I call "tobacco science" necessitated by their "tobacco ethics".  You will be surprised at how many accepted beliefs have been created this way.  There is a chorus of critical scientists; their works need to be studied--they are ignored and often challenged by industries tobacco science.   


Unfortunate the illustrations pasted on to the page in MS word, these illustrations are not showing up now.  A few months ago they were.   Tripod has problems keeping up with the MS Word changes.. For the last 15 years there has been problems with the interface of Tripod program and Microsoft word.  The problems, sometimes lasting over a year, and always--so far--has been corrected.  The material in this section can be followed without those illustrations.   



I have completed about 90% of the book.  The chapters average nearly a month of organizing, and a month of editing, for style, contents, organization, and expansion of materials.  Much of the research had been posted on this website, and there was a internet version.  I then decided to put in in book form without the embedded links.  It is in a book form rather than in journal style.  I shall self publish, then progress to a non-technical version for those who know basic, similar to the 3 books of Gary Taubes.      


In 2011 having realized that scientific fraud was the norm for industry funded work and their key opinion leaders (KOLs), I restarted a new grouping of articles.  Four key areas are bad drugs, medical myths, the harm done by the Western diet, and what to do about it.   All those with a “/r” (for “recommended”) have been posted since 2011.


 


 


Google internal search engine ABOVE & BELOW -- please use


 


MEDICAL LINKS


This site is one of 3 sites maintained by California Skeptics


All with cool art and informative articles   9/9/19


 


#31 TABLE OF CONTENTS healthfully, over 1,200 pages downloaded per day.


 


#7  TABLE OF CONTENTS skeptically, over 8,000 pages downloaded per day.


 


#201 TABLE OF CONTENTS CURRENT NEWS , over 900 pages downloaded per day


 


#157 Video documentaries lectures YouTube Healthful diet, bad pharma, GMOs etc. with description


 


 


#209 THE ARTISTS


 


# 180 RECOMMENDED WESTERN DIET PANDEMIC, high fructose diet and its conditions—proofs 


 


# 181 RECOMMENDED LOW SUGAR POPULATIONS Biomarkers, books, etc.


 


#152 RECOMMENDED--CONCISE Bad drugs, good drugs, treatments & supplements,  


 


#196  RECOMMENDED BOOK WESTERN DIET AND SICKNESS  /rbook some chapters


 


#161  RECOMMENDED HEALTHFUL Improving health including diet and nutritional science


 


#185  RECOMMENDED FRUCTOSE PAMDEMIC BOOK  fructose makes us sick book in preparation


 


 


BUSINESS PROBLEMS:  recommended section since 2010


BAD PHARMA & THEIR TOBACCO SCIENCE


#158  RECOMMENDED GATEWAY PAGE  /rg


#152  RECOMMENDED--CONCISE  /rc Drugs to avoid and take


#182  RECOMMEND ED MYTH BUSTERS   /rmb  on LSP and CAWD before book


#159  RECOMMENDED--LONG   /rl  Topics developed


#160  RECOMMENDED EXPOSING PHARMA   /rep Profits before people


#156  RECOMMENDEDS NON-TECHNICAL SUMMATIONS  /rns Simple info and advice


#176  RECOMMENDED CANCER, STARVING DIET, MACROPHAGEs  /rcdm Cause and starving cancer


#157  RECOMMENDED MORE BAD PHARMA /rmbp More profits before people


#173  RECOMMENDED HEART ISSUES   /rhi


#169  RECOMMENDED HEART CARDIOVASCULAR ISSUES  /rja


#170 RECOMMENDED MORE JOURNAL ARTICLES   /rmja


#166  RECOMMENDED CRITICS      /critics   Those who expose bad pharma


 


DIETARY & DIABETES


#161  RECOMMENDED HEALTHFUL /rh Nutrition in depth, diet myths, plus diets, video links, etc.


#167  RECOMMENDED ARTICLES ON DIET AND FOODS /radf  


#168  RECOMMENDED ARTICLES ON DIETARY ISSUES /radi  


#175  RECOMMENDED DIETARY TOPICS BY JK   /rjk 


#177  RECOMMENDED NEURODEGENERATIVE DISEASES, KETONES   /rndk  


#174  RECOMMENDED DIET TESTIMONIALS   /rdt


#172  RECOMMENDED DIET JOURNAL ARTICLES   /dja


 #178   RECOMMENDED DIABETES   /rt2d


#179  RECOMMENDED WELLNESS CLASS     /rcdm


 


BOOK MATERIAL:  MITOCHONDRIAL DYSFUNCTION & FRUCTOSE


#180  RECOMMENDED WESTERN DIET PANDEMIC    /rmb


#181  RECOMMENDED URIC ACID’S ROLE    /rpc


#182  RECOMMENDED LOW SUGAR POPULATIONS   /rlsp


#183  RECOMMENDED FRUCTOSE, POLYOL PATHWAY, OSMOTIC    /rfpo


#184  RECOMMENDED COLLAGEN AND ASCORBATE (VITAMIN C)   /rca


#185  RECOMMENDED FRUCTOSE PAMDEMIC BOOK  /rfpb


#186  RECOMMENDED GLYCATION END-PRODUCTS, ROS    /rgep


#187  RECOMMENDED MITOCHONDRIAL ARTICLES    /rma


#188  RECOMMENDED FATS (LIPIDS)     /rfl


#189  RECOMMENDED INSULIN RESISTANCE    /rir


#190  RECOMMENDED DIABETES INSULIN RESISTANCE   /rdi


#191  RECOMMENDED LONGER ARTICLE  /rla


#192  RECOMMENDED METABOLIC BASICS EXPLAINED  /rmbe


#193  RECOMMENDED MITOCHONDRIAL DYSFUNCTION  /rmtdd


#194  RECOMMENDED WESTERN DIET DISEASES  /rla


#195  RECOMMENDED RELATED ARTICLESE  /rra


 


OLDER with some newer articles


#17    QUACKERY  (at skeptically.org)


#135  NSAIDS     


#102  QUACK THEORIES & PRACTICES (at skeptically.org)


#41   MEDICAL CRAP


#130  MEDICAL CRAP MORE,


#132  IMAGINARY CONDITIONS


#134  ALTERNATIVE MEDICINE


#136  ENVIRONMENT & HEALTH


#137  DRUG NEWS--DISAPPOINTING


#141  BIG PHARMA AT WORK


#145  MANAGED HEALTH CARE


#146  FDA  Exposing the façade of regulation


#147  FOR THE CHILDREN


#162  CORPORATE DRUGS


#150  BLOOD THINNERS AND ACETAMINOPHEN


#152 INDIGESTION DRUGS


#151  FAILED DRUGS


#159  CRITICS


                    


GENERAL INFORMATION:


#31 INDEX  


#35   HEALTH


#36   WOMEN'S MEDICAL ISSUES


#45   MALE HORMONE REPLACEMENT


#148  FEMALE HORMONE REPLACEMENT


#171  SEX


#154  FOOD


#50   ASPIRIN THE BEST NSAID


#133  THE HEART


#144  HEART MEDICATIONS & TREATMENTS  


#44    ON CANCER


#139  CANCER VARIOUS TISSUES 


#155 CANCER TREATMENTS


#165. CONDITIONS & TREATMENTS


#49    TOBACCO


#131   LONGEVITY


#143  OBESITY


#46    MEDICAL SCIENCE


#47    MEDICAL NEWS


#48    DRUGS AND CONDITIONS


#140   HEALTH & BODY


#138   DISEASES


#142   GERIATRIC PROBLEMS


#149  PSYCHIATRIC DRUGS


#163 NATURALISTIC TREATMENTS (positive)


#153 EFFECTIVE DRUGS


 


MISCELLANEOUS:   


#1 ENLIGHTENMENT


#32 HOME 


#37   BIOGRAPHICAL


#38   LINKS ELSEWHERE


#33  PROSE SATIRE


#34  RHYMED POEMS


#39  RHYMED POEMS ROMANTIC


#40  RHYMED POEMS MELONCHOLY


#42  RHYMED POEMS SOCIAL MESSAGE


#43  RHYMED POEMS SATIRE


#209 THE ARTISTS


#210 SHORT STORY, ETC.


 


e-mail to thinker@skeptically.org


In 2011 having realized that scientific fraud was the norm for industry funded work and their key opinion leaders (KOLs), I restarted a new grouping of articles.  The three key areas of focus are medical myths, the harm down by the Western diet, and what to do about it.   All those with a “/r” (for “recommended”) have been posted since 2011.

Asterix
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First book in 1961, latest 2019

Chapters from my book on what happens on a cellular to our body's when cells aren't working according to their design (evolution).

Selected chapters from the book which has been in preparation since May of 2017, and its topics since 2015.

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Nothing changes while corporatons pick our pocket
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This material was first put up on the internet at   # 180 RECOMMENDED WESTERN DIET PANDEMIC  and # 181 RECOMMENDED LOW SUGAR POPULATIONS.

In 2016 I realized that a book form would do better at getting the message out then what I posted on this site.  I do not expect that my solving the puzzle about cause for conditions associated with the western diet will move the trillion dollar gorillas (pharma and food manufacturers).  

With out the modus operandi, the case against fructose would be speculation, like the work of Burkitt and Trowell who thought the cause was refined carbohydrates.    Current vogue is to blame it on insulin resistance.  Many stop there, and some such as Robert Lustig go on to show that the high sugar diet, and in particular the fructose is a slow acting poison.  But they don't explain how that slow acting poison can cause dementia, cancer, osteoporosis, heart attacks, etc.  Some don't by into insulin resistance as they major cause.  Bruce Ames, corporate media, and Russell Blalock hold an assortment of toxic chemical, stress, and under-nutrition as the major causes.  Lee Knows and Ray Griffiths in their books finger mitochondrial dysfunction, but miss the role of fructose.--possible because they believe the level of fructose (and glucose, both of which are promptly phosphorylated in cells) is very low and there is no way that it can affect the mitochondria. 

With the publishing of the book there will answer on how fructose harms the mitochondria, and how this damage affects every cell in the body. 

   

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Salvador Dali

Why We Get Sick, the High Sugar Diet and Mitochondrial Dysfunction: A survey of the evidence, and how to help your body heal 8/27/19.

SECTION 1: LOW SUGAR POPULATIONS 1) Uric acid—sensitivity to and consequences

1) Conditions of low sugar populations 2) Endothelial dysfunction and uric acid

2) Burkitt and Trowel’s book 3) Under production of collagen & cholesterol

3) Problems of gathering data 4) Drugs and other chemicals causing CAWD

4) How industries frame the topics; some consequences 5) ROS & fructation of polyunsaturated fats

SECTION 2: FRUCTOSE SLOW POISON

6) The combined theory of aging

1) Basic-background knowledge SECTION 5: CONDITIONS ASSOCIATED WITH THE WESTERN DIET (CAWD)

2) Fructose receptors jejunum 1) B-4 and risk measurements

3) Fructose consumption, numbers, KOLs 2) B-4 conditions

4) Fructose through fructation causes MTDD SECTION 6: THE FIXES

5) Polyol pathway and conversion of glucose to fructose in every cell 1) Autophagy the repair replace, and recycle systems

SECTION 3: MITOCHONDRIAL DYSFUNCTION (MTDD)—and the consequences of the underproduction of ATP 2) sex and related hormones fine tune autophagy

1) MTD structure and metabolism 3) Supplements

2) MTD functions other than metabolism 4) The Basics and why popular diets fail

3) MTD lipid droplets, and NAFLD

4) MTDD CC IR, LR, lipophilia, diabetes

5) Drugs causing MTDD

SECTION 4: CONTRIBUTING CAUSES FOR CAWD

1) Uric acid—sensitivity to and consequences

2) Endothelial dysfunction and uric acid

3) Under production of collagen & cholesterol

4) Drugs and other chemicals causing CAWD

5) ROS & fructation of polyunsaturated fats

6) The combined theory of aging

SECTION 5: CONDITIONS ASSOCIATED WITH THE WESTERN DIET (CAWD)

1) B-4 and risk measurements

2) B-4 conditions

SECTION 6: THE FIXES

1) Autophagy the repair replace, and recycle systems

2) sex and related hormones fine tune autophagy

3) Other supplements

4) The Basics and why popular diets fail

5) fasting and exercise

6) Insulin, ketogenic, and autophagy

7) Bad industries, bad messages, cognitive dissonance

8) Social environment


~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

B-4 fructose, MTDD, RATP, RRA, CAWD conditions associated with the western diet, IR insulin resistance, KOL key opinion leader, LR Leptin resistance MTD mitochondria (/al), MTDD mitochondrial dysfunction, NAFLD non-alcoholic liver disease, RATP reduce ATP, RRA reduced rate of autophagy

On how daily excessive fructose damages the mitochondria and thus is the main cause for the conditions associated with the Western diet--much, much, more the cause than insulin resistance, type-2 diabetes, and weight gain, all of which are caused by mitochondrial dysfunction, which starts first in the liver.