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Guide Des 4,000 Medicaments by Drs. Evan & Debre, Sept. 2012. As of 8/2013 the book is not available in English. Translanted: "The Guide to the 4,000 Useful, Useless or Dangerous Medicines".

They are particularly harsh about lipid-regulating statins and have singled out 58 drugs, that are used for a wide range of conditions, like diabetes and osteoporosis, which they claim are outright dangerous.

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half the 4,000 drugs are useless and dangerous

In 2011 having realized that scientific fraud was the norm for industry funded work and their key opinion leaders (KOLs) wrote the medical textbooks, guidelines, signed off on clinical trials, educated practicing physicians in CME class, and that physicians were dupes of pharma, I restarted a new grouping of articles. Six key areas are bad pharma, YouTube documentaries and lectures exposing the crapolla, bad drugs and bad medical pracatices, medical myths, the harm done by the Western diet, and what to do about it. All those sites with a “/r” (for “recommended”) have been posted since 2011.

Google internal search engine ABOVE & BELOW -- please use

MEDICAL LINKS

This site is one of 3 sites maintained by California Skeptics

All with cool art and informative articles 9/10/2020

#31 TABLE OF CONTENTS healthfully, over 1,200 pages downloaded per day.

#7 TABLE OF CONTENTS skeptically, over 8,000 pages downloaded per day.

#201 Recommended JK BOOK, How Fructose poisons every cell, A textbook on conditions associated with western diet

#157 Video documentaries lectures YouTube Healthful diet, bad pharma, GMOs etc. with description

#209 THE ARTISTS

# 180 RECOMMENDED WESTERN DIET PANDEMIC, high fructose diet and its conditions—proofs

# 181 RECOMMENDED LOW SUGAR POPULATIONS Biomarkers, books, etc.

#152 RECOMMENDED--CONCISE Bad drugs, good drugs, treatments & supplements,

#196 RECOMMENDED BOOK WESTERN DIET AND SICKNESS /rbook some chapters

#161 RECOMMENDED HEALTHFUL Improving health including diet and nutritional science

#185 RECOMMENDED FRUCTOSE PAMDEMIC BOOK fructose makes us sick: JK’s book on how

BUSINESS PROBLEMS: recommended section since 2010

BAD PHARMA & THEIR TOBACCO SCIENCE

#158 RECOMMENDED GATEWAY PAGE /rg

#152 RECOMMENDED--CONCISE /rc Drugs to avoid and take

#182 RECOMMEND ED MYTH BUSTERS /rmb on LSP and CAWD before book

#159 RECOMMENDED--LONG /rl Topics developed

#160 RECOMMENDED EXPOSING PHARMA /rep Profits before people

#156 RECOMMENDEDS NON-TECHNICAL SUMMATIONS /rns Simple info and advice

#176 RECOMMENDED CANCER, STARVING DIET, MACROPHAGEs /rcdm Cause and starving cancer

#157 RECOMMENDED MORE BAD PHARMA /rmbp More profits before people

#173 RECOMMENDED HEART ISSUES /rhi

#166 RECOMMENDED CRITICS /critics Those who expose bad pharma

DIETARY & DIABETES

#161 RECOMMENDED HEALTHFUL /rh Nutrition in depth, diet myths, plus diets, video links, etc.

#174 RECOMMENDED DIET TESTIMONIALS /rdt

#178 RECOMMENDED DIABETES /rt2d

#179 RECOMMENDED WELLNESS CLASS /rcdm

BOOK MATERIAL: MITOCHONDRIAL DYSFUNCTION, FRUCTOSE, and CONSEQUENCES

#181 RECOMMENDED URIC ACID’S ROLE /rpc

#182 RECOMMENDED LOW SUGAR POPULATIONS /rlsp

#185 RECOMMENDED FRUCTOSE PAMDEMIC BOOK /rfpb

#188 RECOMMENDED FATS (LIPIDS) /rfl

#189 RECOMMENDED INSULIN RESISTANCE /rir

#191 RECOMMENDED LONGER ARTICLE /rla

#193 RECOMMENDED MITOCHONDRIAL DYSFUNCTION /rmtdd

#195 RECOMMENDED RELATED ARTICLES /rra

#196 RECOMMENDED AUTOPHAGY (HEALING) /rapy

#197 RECOMMENDED AGING THEORIES /rat

#198 RECOMMENDED FRUCOSE POISON /rep

OLDER with some newer articles

#17 QUACKERY (at skeptically.org)

#135 NSAIDS

#102 QUACK THEORIES & PRACTICES (at skeptically.org)

#41 MEDICAL CRAP

#130 MEDICAL CRAP MORE,

#132 IMAGINARY CONDITIONS

#134 ALTERNATIVE MEDICINE

#136 ENVIRONMENT & HEALTH

#137 DRUG NEWS--DISAPPOINTING

#141 BIG PHARMA AT WORK

#145 MANAGED HEALTH CARE

#146 FDA Exposing the façade of regulation

#147 FOR THE CHILDREN

#162 CORPORATE DRUGS

#150 BLOOD THINNERS AND ACETAMINOPHEN

#152 INDIGESTION DRUGS

#151 FAILED DRUGS

#159 CRITICS

GENERAL INFORMATION:

#31 INDEX

#35 HEALTH

#36 WOMEN'S MEDICAL ISSUES

#45 MALE HORMONE REPLACEMENT

#148 FEMALE HORMONE REPLACEMENT

#171 SEX

#154 FOOD

#50 ASPIRIN THE BEST NSAID

#133 THE HEART

#144 HEART MEDICATIONS & TREATMENTS

#44 ON CANCER

#139 CANCER VARIOUS TISSUES

#155 CANCER TREATMENTS

#165. CONDITIONS & TREATMENTS

#143 OBESITY

#48 DRUGS AND CONDITIONS

#140 HEALTH & BODY

#138 DISEASES

#142 GERIATRIC PROBLEMS

#149 PSYCHIATRIC DRUGS

#163 NATURALISTIC TREATMENTS (positive)

#153 EFFECTIVE DRUGS

MISCELLANEOUS:

#39 RHYMED POEMS ROMANTIC

#40 RHYMED POEMS MELONCHOLY

#42 RHYMED POEMS SOCIAL MESSAGE

#43 RHYMED POEMS SATIRE

#209 THE ARTISTS

#210 SHORT STORY, ETC.

e-mail to thinker@skeptically.org

In 2011 having realized that scientific fraud was the norm for industry funded work and their key opinion leaders (KOLs), I restarted a new grouping of articles. The five key areas of focus are medical myths, bad pharma, bad drugs-treatments, the harm down by the Western diet, and what to do about it. All those with a “/r” (for “recommended”) have been posted since 2011.

Google internal search engine ABOVE & BELOW -- please use

A thought experiment: Think like the CEO of Merck (a wealthy marketing executive whose standard of review by the Board of Directors is based on the Merck’s maximization of quarterly profits. You are a hands-on CEO who reviews essential aspects of the business. In the pipeline is a new type of heart medication which will replace the off patent Zocor. The FDA has agreed not require prevention of death or lower incidence of heart attacks, but merely for the drug a PCSK9 inhibitor, Zetia, to lower cholesterol, which is a surrogate outcome. You review the conditions for the phase III trial which will be submitted to the FDA for approval. By using a surrogate outcome, it entails that you don’t have to use a control group who take a placebo. There is no troubling control group to compare deaths and heart attacks. The statin Zocor in 2 later phase IV trials failed to demonstrate compared to a placebo group that Zocor prevented heart attacks and deaths. Fortunately you didn’t have to submit those negative results to the FDA, or publish them in journal. You select a patient population which has familial hypercholesterolemia (their total cholesterol averages 3 times the norm). This population of 300 averages 30 years of age (older volunteers would have more side effects including deaths and heart attacks) is ideal. You run the trial for just 9 weeks to lower the side effects, most of which take months to develop. Unlike the journals, the FDA is given all the raw data from phase III trials. Journals are not given the raw data. Once approved, you will then expand usage on the basis of testing with junk marketing science, called “phase IV studies” and then publish them. No FDA approval is needed for new usages as long as Merck doesn’t advertise the new usage. However, you will order tens-of-thousands of reprints of the tobacco science phase IV trial’s journal articles to distribute to doctors by your sales reps. You are now running a phase IV trial on Alzheimer’s disease. Your KOLs will instruct physician on Zetia uses in required continuing education class funded by Merck. You schmooze with “donations” politicians, regulators, health care administrators, physicians, and medical organizations. The American Heart Association will establish treatment guidelines for Zetia using a panel of your KOLs which justify the treatment with your junk science. Civil courts plus administrators in hospitals and clinics pressure doctors to follow those guidelines. Merck’s television advertising blitz will exaggerate disease risks, hype benefits, and hides side effects. See Side Effects and Marketing Science for an “ad nausea” account of pharma. This is a way all large drug companies do business

Google internal search engine ABOVE & BELOW -- please use

MEDICAL LINKS

This site is one of 3 sites maintained by California Skeptics

All with cool art and informative articles 4/30/17

NEW

#176 RECOMMENDED CANCER, DIET, MACROPHAGE Cause and starving cancer

#175 RECOMMENDED DIETARY TOPICS BY JK

#31 TABLE OF CONTENTS healthfully, over 1,200 pages downloaded per day.

#7 TABLE OF CONTENTS skeptically, over 8,000 pages downloaded per day.

#201 TABLE OF CONTENTS CURRENT NEWS , over 900 pages downloaded per day

#209 THE ARTISTS

# 220 POD CASTS & U-TUBE, for those who like the visual on skeptical issues

#158 RECOMMENDED GATEWAY PAGE Gateway to the research on pharma and health

#152 RECOMMENDATIONS--CONCISE Bad drugs, good drugs, contra pharma

#161 RECOMMENDED HEALTHFUL Improving health including diet and nutritional science

#157 Video documentaries, mostly YouTube Healthful diet, bad pharma, GMOs etc. with description

BUSINESS PROBLEMS:

#158 RECOMMENDED GATEWAY PAGE

#152 RECOMMENDATIONS--CONCISE Drugs to avoid and take

#159 RECOMMENDATIONS--LONG Topics developed

#160 RECOMMENDED EXPOSIING PHARMA Profits before people

#161 RECOMMENDED HEALTHFUL Nutrition in depth, diet myths, plus diets

#156 RECOMMENDATIONS NON-TECHNICAL SUMMATIONS Simple info

#157 RECOMMENDED MORE BAD PHARMA More profits before people

#166 RECOMMENDED CRITICS

#175 RECOMMENDED DIETARY TOPICS BY JK Concise non-technical

#174 RECOMMENDED DIET TESTIMONIALS

#169 RECOMMENDED JOURNAL ARTICLES

#170 RECOMMENDED MORE JOURNAL ARTICLES

#172 RECOMMENDED DIET JOURNAL ARTICLES

#173 RECOMMENDED HEART ISSUES

#17 QUACKERY (at skeptically.org)

#135 NSAIDS

#102 QUACK THEORIES & PRACTICES (at skeptically.org)

#41 MEDICAL CRAP

#130 MEDICAL CRAP MORE,

#132 IMAGINARY CONDITIONS

#134 ALTERNATIVE MEDICINE

#136 ENVIRONMENT & HEALTH

#137 DRUG NEWS--DISAPPOINTING

#141 BIG PHARMA AT WORK

#145 MANAGED HEALTH CARE

#146 FDA Exposing the façade of regulation

#147 FOR THE CHILDREN

#162 CORPORATE DRUGS

#150 BLOOD THINNERS AND ACETAMINOPHEN

#152 INDIGESTION DRUGS

#151 FAILED DRUGS

#159 CRITICS

GENERAL INFORMATION:

#31 INDEX

#35 HEALTH

#36 WOMEN'S MEDICAL ISSUES

#45 MALE HORMONE REPLACEMENT

#148 FEMALE HORMONE REPLACEMENT

#171 SEX

#154 FOOD

#50 ASPIRIN THE BEST NSAID

#133 THE HEART

#144 HEART MEDICATIONS & TREATMENTS

#44 ON CANCER

#139 CANCER VARIOUS TISSUES

#155 CANCER TREATMENTS

#165. CONDITIONS & TREATMENTS

#143 OBESITY

#48 DRUGS AND CONDITIONS

#140 HEALTH & BODY

#138 DISEASES

#142 GERIATRIC PROBLEMS

#149 PSYCHIATRIC DRUGS

#163 NATURALISTIC TREATMENTS (positive)

#153 EFFECTIVE DRUGS

MISCELLANEOUS:

#39 RHYMED POEMS ROMANTIC

#40 RHYMED POEMS MELONCHOLY

#42 RHYMED POEMS SOCIAL MESSAGE

#43 RHYMED POEMS SATIRE

#209 THE ARTISTS

#210 SHORT STORY, ETC.

e-mail to thinker@skeptically.org

There is grass root revulsion to the current corporate health industry, with pharma doing the most harm. The best account of bad pharma is by Danish Prof. Peter Gotzsche in his 2013 book Deadly Medicine and Organised Crime: How big pharma has corrupted healthcare. Prof. Gotzsche’s book has won the British Medical Book Award given by the BMA (British Medical Association which is comparable to our AMA). Further endorsement comes from the Richard Smith former Editor-in-Chief of the BMJ (British Medical Journal) and Drummond Rennie, Deputy Editor of JAMA (Journal of American Medical Association) which are 2 of the 4 leading English medical journal. The President’s Lecture on YouTube by Harvard Professor Marcia Angell confirms Prof. Gotzsche’s book. Pharma is worse than you can imagine.

Todd Shorr

Like so much of pharma influenced research accounts there is one promoted by pharma’s KOLs, (key opinion leaders), the other without their biases. This happens with atherosclerosis (AS) and its child coronary artery disease. One account doesn’t usually mention pathogens, or on a few occasions lists it as an adjunction causal factor along with diabetes, hypertension, and smoking. Some pharma accounts state that the process starts with endothelial dysfunction as promoting oxidation of LDL. Either way they explain the role of LDL as that of a victim of reactive chemicals, rather than its role absorbing toxins and other reactive chemicals generated by the pathogens. Troubling about the first account, besides ignoring the role of pathogens, is that it doesn’t convincingly explain why the LDL is subject to damage by reactive chemicals in the rather protected pathogen free environment inside the artery wall. Why not while in the turbulent travel through the blood vessels? The role of mopping up toxins generated by pathogens has been documented; the putative reaction of white blood cells to oxidation of LDL from other sources is more tenuous. Why does macrophages engulf oxidized damaged LDL, but not other damaged tissues? It seems like the process is stretched to fit the theory, a theory where pathogens are usually ignored. But the experimental evidence is clearly compelling for pathogens having the primary role in starting the cascade of events leading to AS. For as sample of those article click on these two links. This ignoring the evidence follows a pattern of promoting profits before patient health. I have carefully researched over 6 such examples. This is what we get when corporations take control of a product, I call it tobacco ethics. Three glaring examples of this type of ethic including the marketing of tobacco, alcoholic beverages, and sugar added manufactured food products.

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INTERNAL SITE SEARCH ENGINE by Google

Disclaimer: The information, facts, and opinions provided here is not a substitute for professional advice. It only indicates what JK believes, does, or would do. Always consult your primary care physician for medical advice, diagnosis, and treatment.