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Guide Des 4,000 Medicaments by Drs. Evan & Debre, Sept. 2012.  As of 8/2013 the book is not available in English.  Translanted:  "The Guide to the 4,000 Useful, Useless or Dangerous Medicines". 

They are particularly harsh about lipid-regulating statins and have singled out 58 drugs, that are used for a wide range of conditions, like diabetes and osteoporosis, which they claim are outright dangerous. 

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half the 4,000 drugs are useless and dangerous
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Dr Evans said in an interview to the Guardian:  “The pharmaceutical industry is the most lucrative, the most cynical and the least ethical of all the industries," Dr. Philippe Even tells The Guardian. "It is like an octopus with tentacles that has infiltrated all the decision-making bodies:  world health organizations, government agencies, parliaments, high administrations in health and hospitals and the medical profession."

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A thought experiment:  Think like the CEO of Merck (a wealthy marketing executive whose standard of review by the Board of Directors is based on the Merck’s maximization of quarterly profits.  You are a hands-on CEO who reviews essential aspects of the business.  In the pipeline is a new type of heart medication which will replace the off patent Zocor.  The FDA has agreed not require prevention of death or lower incidence of heart attacks, but merely for the drug a PCSK9 inhibitor, Zetia, to lower cholesterol, which is a surrogate outcome.  You review the conditions for the phase III trial which will be submitted to the FDA for approval.  By using a surrogate outcome, it entails that you don’t have to use a control group who take a placebo. There is no troubling control group to compare deaths and heart attacks.  The statin Zocor in 2 later phase IV trials failed to demonstrate compared to a placebo group that Zocor prevented heart attacks and deaths.  Fortunately you didn’t have to submit those negative results to the FDA, or publish them in journal.  You select a patient population which has familial hypercholesterolemia (their total cholesterol averages 3 times the norm).  This population of 300 averages 30 years of age (older volunteers would have more side effects including deaths and heart attacks) is ideal.  You run the trial for just 9 weeks to lower the side effects, most of which take months to develop.  Unlike the journals, the FDA is given all the raw data from phase III trials.  Journals are not given the raw data.  Once approved, you will then expand usage on the basis of testing with junk marketing science, called “phase IV studies” and then publish them. No FDA approval is needed for new usages as long as Merck doesn’t advertise the new usage.  However, you will order tens-of-thousands of reprints of the tobacco science phase IV trial’s journal articles to distribute to doctors by your sales reps.  You are now running a phase IV trial on Alzheimer’s disease.  Your KOLs will instruct physician on Zetia uses in required continuing education class funded by Merck.   You schmooze with “donations” politicians, regulators, health care administrators, physicians, and medical organizations.  The American Heart Association will establish treatment guidelines for Zetia using a panel of your KOLs which justify the treatment with your junk science.  Civil courts plus administrators in hospitals and clinics pressure doctors to follow those guidelines.  Merck’s television advertising blitz will exaggerate disease risks, hype benefits, and hides side effects.  See Side Effects and Marketing Science for an “ad nausea” account of pharma.  This is a way all large drug companies do business




MEDICAL LINKS

This site is one of 3 sites maintained by California Skeptics

All with cool art and informative articles   11/27/16

 

#31 TABLE OF CONTENTS healthfully, over 1,200 pages downloaded per day.

 

#7  TABLE OF CONTENTS skeptically, over 8,000 pages downloaded per day.

 

#201 TABLE OF CONTENTS CURRENT NEWS , over 900 pages downloaded per day

 

#209 THE ARTISTS

 

# 220 POD CASTS & U-TUBE, for those who like the visual on skeptical issues

 

#158   RECOMMENDED GATEWAY PAGE  Gateway to the research on pharma and health

 

#152 RECOMMENDATIONS--CONCISE Bad drugs, good drugs, contra pharma

 

#161  RECOMMENDED HEALTHFUL Improving health including diet and nutritional science

 

#157 Video documentaries, mostly YouTube Healthful diet, bad pharma, GMOs etc. with description

 

 

 BUSINESS PROBLEMS:

#158   RECOMMENDED GATEWAY PAGE

#152  RECOMMENDATIONS--CONCISE Drugs to avoid and take

#159  RECOMMENDATIONS--LONG Topics developed

#160  RECOMMENDED EXPOSIING PHARMA Profits before people

#161  RECOMMENDED HEALTHFUL Nutrition in depth, diet myths, plus diets

#156  RECOMMENDATIONS NON-TECHNICAL SUMMATIONS  Simple info

#157  RECOMMENDED MORE BAD PHARMA More profits before people

#166  RECOMMENDED CRITICS

#175  RECOMMENDED DIETARY TOPICS BY JK  Concise non-technical

#167  RECOMMENDED ARTICLES ON DIET AND FOODS

#168  RECOMMENDED ARTICLES ON DIETARY ISSUES

#174  RECOMMENDED DIET TESTIMONIALS

#169 RECOMMENDED JOURNAL ARTICLES

#170 RECOMMENDED MORE JOURNAL ARTICLES

#172  RECOMMENDED DIET JOURNAL ARTICLES

#173  RECOMMENDED HEART ISSUES

#17    QUACKERY  (at skeptically.org)

#135  NSAIDS

#102  QUACK THEORIES & PRACTICES (at skeptically.org)

#41   MEDICAL CRAP

#130  MEDICAL CRAP MORE,

#132  IMAGINARY CONDITIONS

#134  ALTERNATIVE MEDICINE

#136  ENVIRONMENT & HEALTH

#137  DRUG NEWS--DISAPPOINTING

#141  BIG PHARMA AT WORK

#145  MANAGED HEALTH CARE

#146  FDA  Exposing the fašade of regulation

#147  FOR THE CHILDREN

#162  CORPORATE DRUGS

#150  BLOOD THINNERS AND ACETAMINOPHEN

#152 INDIGESTION DRUGS

#151  FAILED DRUGS

#159  CRITICS

                    

 

GENERAL INFORMATION:

#31 INDEX  

#35   HEALTH

#36   WOMEN'S MEDICAL ISSUES

#45   MALE HORMONE REPLACEMENT

#148  FEMALE HORMONE REPLACEMENT

#171  SEX

#154  FOOD

#50   ASPIRIN THE BEST NSAID

#133  THE HEART

#144  HEART MEDICATIONS & TREATMENTS  

#44    ON CANCER

#139  CANCER VARIOUS TISSUES 

#155 CANCER TREATMENTS

#165. CONDITIONS & TREATMENTS

#49    TOBACCO

#131   LONGEVITY

#143  OBESITY

#46    MEDICAL SCIENCE

#47    MEDICAL NEWS

#48    DRUGS AND CONDITIONS

#140   HEALTH & BODY

#138   DISEASES

#142   GERIATRIC PROBLEMS

#149  PSYCHIATRIC DRUGS

#163 NATURALISTIC TREATMENTS (positive)

#153 EFFECTIVE DRUGS

 

MISCELLANEOUS:   

#1 ENLIGHTENMENT

#32 HOME 

#37   BIOGRAPHICAL

#38   LINKS ELSEWHERE

#33  PROSE SATIRE

#34  RHYMED POEMS

#39  RHYMED POEMS ROMANTIC

#40  RHYMED POEMS MELONCHOLY

#42  RHYMED POEMS SOCIAL MESSAGE

#43  RHYMED POEMS SATIRE

#209 THE ARTISTS

#210 SHORT STORY, ETC.

 

 

 

e-mail to thinker@skeptically.org

 

There is grass root revulsion to the current corporate health industry, with pharma doing the most harm.  The best account of bad pharma is by Danish Prof. Peter Gotzsche in his 2013 book Deadly Medicine and Organised Crime:  How big pharma has corrupted healthcare.  Prof. Gotzsche’s book has won the British Medical Book Award given by the BMA (British Medical Association which is comparable to our AMA).  Further endorsement comes from the Richard Smith former Editor-in-Chief of the BMJ (British Medical Journal) and Drummond Rennie, Deputy Editor of JAMA (Journal of American Medical Association) which are 2 of the 4 leading English medical journal.   The President’s Lecture on YouTube by Harvard Professor Marcia Angell confirms Prof. Gotzsche’s book. Pharma is worse than you can imagine.       

 

Todd Shorr
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Like so much of pharma influenced research accounts there is one promoted by pharma’s KOLs, (key opinion leaders), the other without their biases.  This happens with atherosclerosis (AS) and its child coronary artery disease.  One account doesn’t usually mention pathogens, or on a few occasions lists it as an adjunction causal factor along with diabetes, hypertension, and smoking.  Some pharma accounts state that the process starts with endothelial dysfunction as promoting oxidation of LDL.  Either way they explain the role of LDL as that of a victim of reactive chemicals, rather than its role absorbing toxins and other reactive chemicals generated by the pathogens.  Troubling about the first account, besides ignoring the role of pathogens, is that it doesn’t convincingly explain why the LDL is subject to damage by reactive chemicals in the rather protected pathogen free environment inside the artery wall.  Why not while in the turbulent travel through the blood vessels?  The role of mopping up toxins generated by pathogens has been documented; the putative reaction of white blood cells to oxidation of LDL from other sources is more tenuous.  Why does macrophages engulf oxidized damaged LDL, but not other damaged tissues?  It seems like the process is stretched to fit the theory, a theory where pathogens are usually ignored.  But the experimental evidence is clearly compelling for pathogens having the primary role in starting the cascade of events leading to AS. For as sample of those article click on these two links.  This ignoring the evidence follows a pattern of promoting profits before patient health.  I have carefully researched over 6 such examples.  This is what we get when corporations take control of a product, I call it tobacco ethics.  Three glaring examples of this type of ethic including the marketing of tobacco, alcoholic beverages, and sugar added manufactured food products. 

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Disclaimer:  The information, facts, and opinions provided here is not a substitute for professional advice.  It only indicates what JK believes, does, or would do.  Always consult your primary care physician for medical advice, diagnosis, and treatment.