Obesity
and Type-2
Diabetes: Healing, What To Do and Why
www.healthfully.org/rns/id6.html
7/23/16 (see first definitions
on last page)
The systems and why it fails: There are 2 main systems for producing the energy molecule ATP, one of
burning glucose, the other of fats. Obesity
& T-2D result from a defect in the fat-weight-regulatory system. All mammals
have a complex regulatory system for appetite, rate of metabolism, and fat storage.
There are over eighty hormones involved in
the systems. The Western diet has 30% calories
from sugars (788 calories), mostly from sucrose. The most reactive sugar is fructose; it is one
half of the disaccharide sucrose. It accumulates
in the liver because that is where it is metabolized. There it damages the liver
through the
process of glycation. Glycation is the
process of a sugar and its metabolites randomly attaching to proteins. This
damage in the liver causes insulin
resistance (IR) which entails a higher than
normal level of insulin is necessary to promote the uptake of blood glucose by
cells throughout the body. Refined &
also easily digested carbohydrates such as from rice and potatoes accelerate
the process leading to insulin resistance and fatty liver disease (NAFLD)
because they cause a very high blood glucose level.[1] Insulin direct cells
throughout the body to absorb blood glucose which the cells will burn
(metabolize). To promote glucose
burning, insulin also signals cells to stop burning fat and thus STORE THE FAT. Thus IR causes an
excess in fat storage. Some
of that fat is stored in the liver, and
in excess (2-3 pounds) this further damages the liver. These stresses upon the
liver (from glycation
& excess fat) are what throws-out of balance the weight control system. Too
much fat in the pancreas damages the pancreas causes T2D. The US western diet
with its average of 151
pounds yearly of sugar has caused through liver damage a health disaster.
A
few more pieces to the system: more on what you need to know are the causes
so that you will know how fasting and low sugar diet fixes the weight-regulatory
system. Fructose is a 7.5 times more
reactive than glucose, and it takes twice as long as glucose to be cleared from
the liver; thus it damages the liver at 15 times the rate of glucose.
Experiments have shown that high fructose diet causes liver inflammation. Galactose
from milk sugar lactose is also
very reactive. Incretins are hormones
produced in the stomach and duodenum in response to foods. They stimulate the
release of insulin by the
pancreas. This explains why all foods
cause the release of insulin even the ones that don’t have glucose
(carbs). See Insulin Table at the end
for the amounts. It is another reason
why a very low carb diet fails long-term, because the insulin in response to
proteins prevents the clearance of fat from the liver and pancreas. Insulin
also regulates the hormone
leptin. Having IR will over time result in leptin resistance (excess leptin). Leptin
produced by fat (adipose) tissue and functions
to maintain at a fixed level of fat through its affects upon appetite and
metabolism. When the fat level stored
drops low it functions to both increase appetite and cause a major reduction in
metabolism. This leptin system with
other hormones functions to restore weight, a good thing if you are thin, but a
bad thing if you are long-term overweight.
This leptin production by fat tissues explains why it is so hard for
some people to lose weight and keep it off—the yo-yo diets. Western diet
has through excess insulin made many
of us overweight, obese, and diabetic. Exercise
more and eat less doesn’t fix the system.
The
fix: Cleanse the fatty liver & pancreas through extended
periods of low insulin. At night
after the food has been digested and blood glucose returns to the fasting level
(which is what your doctor measures with blood work in the morning) the body is
metabolizing fats, insulin is very low.
This period of fat burning, if frequent and long enough, will burn the
excess fat in the liver and pancreas. When
on a low carb/sugar diet helped along by fasting, this will permit the liver
and pancreas to heal and function normally:
the cure for NAFLD, IR and T2D. Merely
low carb or low calories will not keep insulin sufficiently low to allow the
metabolism of the excess fat in the liver or to avoid the lipophilic effect of
leptin to restore the fat by increasing appetite and lowering metabolism. Remember
that leptin is secreted in response
to insulin. Fasting enhanced by low
carbs avoids the drop in metabolism that occurs through leptin to restore fat
Cleansing the liver of fat prevents
the yo-yo diet.
What
you probably won’t hear this from your doctors and corporate media: Medical schools do not have a
course in nutrition. The influence of
the pharma and food manufacturers also extends to clinical trials and who rises
to be a key opinion leaders and what they teach. Because it is not in their
financial interest
to fix the NAFLD and IR with diet and thereby prevent all the comorbidities,
your doctor is taught that the ketogenic diet is dangerous, fasting doesn’t
work, and he will advises you to eat less and exercise more. The same message
is taught dieticians and
repeated in the corporate press. They
are taught the fix is to eat less and exercise more and for diabetes to tightly
manage glucose with drugs, and that diabetes is a progressive disease. It is
tragic that industries are allowed in
our corporatist state to pollute the evidence, corrupt medical education, and
clinical practices.
JK
short fast (SF):
go on a 16 hour fast (7 PM until 11:00 AM) or longer, thus extending
nighttime fat burning to midday. At
night because of not eating there is low glucose and thus low insulin. If
hunger becomes an issue, than drink tea
or coffee without sweeteners or milk.
Yes, no artificial sweeteners[2]. If quite hungry then eat a little celery or
like greens, preferable without cheese or peanut butter, or similar small
snack. If progress is slow than lower
carbs more and progress to the alternate day fasting. You can still delay your
first meal on the
non-fasting days. Choose whichever fast
has the best compliance, Dr. Fung prefers alternate day fasting, but uses
either based upon compliance.
The
fat burning diet: It starts in the
supermarket: buy low net carb foods (net
carbs
= total carbohydrates minus fiber content in grams), and clean out your
cupboards and fridge.
It is easier to say “no” in the market then in the kitchen. We
are a social animal, thus enlist the support of
your family and friends. A positive vicarious social contact arises
from watching the diet and diabetes documentaries and lectures on YouTube; and it enlists the support
of the rational side of your
brain. An extensive list of YouTube
videos with description is at http://healthfully.org/rh/id7.html. Keep a log of your
diet and fasting including how you feel.
Start the log a couple of weeks before starting your diet and fasting. For
some the gradual approach is best. With this method you can reduce your carbs
gradually and substitute corn syrup for sugar.
Karo is the leading brand; it is pure glucose (no fructose). Biologically
it is equivalent to rice and
potatoes. It took me 3 months to lose my
craving for sweets; a year to reduce to 1/3rd refined carbs—and I
have always been slim. Right from the
start I increased saturated fats (butter) to replace the reduction in carbs.
Yes, fats are much better for you than refined carbs and yes, saturated fats
are the best, followed by monounsaturated fats.
(See links section below for the science behind why saturated fats are
much better than the cheap unhealthy processed polyunsaturated fats which food
manufactures along with added sugars use).
To obtain the long periods of
low
insulin requires fasting. An early,
small dinner, low in carbs and high fat, moderate protein[3]
entails more hours at night in the fat-burning state. If short-term fasting
isn’t working to cure
T2D and obesity, then switch to alternate day fasting and continue to reduce
the carbohydrates.
Additional
good diet practices:
Short-term
fast, don’t eat
after 7 PM and skip breakfast.
To
lower insulin spike when
eating refined carbs include a liberal dose of fat and/or protein
Exercise
prior to and
subsequent to eating, thus lowering blood glucose and thus insulin
Smaller
meals have lower
insulin spike and quicker clearance from gastro-intestinal track
Preferentially buy carbs
that are high in resistant starches (see /rh/id3.html) such as from legumes
and/or fiber such as green-leafy vegetables
Increase saturated fats to
supply the energy that carbs were supplying & greater satiety
Avoid the products of the
food manufactures; for they are have added sugar, refined carbs,
polyunsaturated and trans-fats, and chemical additives
At meal-time eat slowly and
stop before stuffed
Have handy small low carb
snacks to kill hunger pangs
LINKS: The best source on what to eat for health, for diet,
and related topics is at Concise. In the rh section
are articles which lay out the evidence for what is found there and dja has
journal articles on rancid fats, diet, etc.
Important are Part 5 on supplements, Part 6 which covers
many of the topics here, and Part 10 on the New
Atkins low-carb diet. The large Videos library with brief
descriptions has links
to YouTube. It confirms the claims
here--and other health topic. The links
to ABC, CBC, BBC, ABC again
national networks; they expose what U.S. media hides. The leading authority
with results is Dr. Fung of Toronto;
his videos on YouTube are on fasting, T2D, fats, & insulin. I highly recommend his book “The
Obesity Code: Unlocking The Secretes of
Weight Loss” (a book on fasting is coming out in October of 2016). For
those with T2D, for a minimal fee your he
will work with your doctor, click on the link to his clinic.
Definitions: body &
food basics
Adipocytes
(lipocytes) fat cells compose adipose
tissue & secrete hormones resistin, adiponectin, leptin and apelin.
ATP, Adenosine TriPhosphate (adenosine
with 3 phosphate molecules (PO4) attached), transfers chemical energy within
the cell through the loss of one of its phosphate groups. In the mitochondria ADP
returns to the high energy state ATP 3(PO4) through absorbing energy
from the metabolism of carbohydrates & fats. ATP
provides the energy for over 90% of the biosynthesis: for muscle contraction,
hormones, collagen,
etc. and for intra and intercellular active transport.
Cardiovascular
disease (CVD) causes cigarettes
and a high sugar diet which cause endothelial
dysfunction of the artery
walls. These
cells permit pathogens
to colonize in the artery walls to cause
inflammation, atherosclerosis,
and CVD.
Carbohydrate
(carb): fiber, fructose,
glucose-glycogen, starch, sucrose, lactose, net carbs (total
carbs minus fiber):
Fiber,
vegetable fiber, roughage, the carbohydrate component not broken down
by digestive
enzymes, but some is by gut bacteria.
Fiber has more than ten sugar units.
It lowers the insulin spike when consumed with refined carbs.
Fructose (fruit sugar) a
monosaccharide found in fruits. Main
sources are the disaccharide sucrose, fruits, and high fructose corn syrup. It is metabolized in the liver into either
glucose, or fat which when
insulin is stored there to cause fatty liver.
Also fructose is 7.5 more reactive then glucose and by glycation damages
the liver, etc.
Glucose a monosaccharide is the main energy
storage molecule for plants; in humans 1-2-lbs is stored as long-chain glycogen
a backup energy source stored in muscles, fat, and liver cells. Glucose
is as one half of sucrose, and is
also obtained from the hydrolysis of the digestible starches. Glucose and fat
are the main sources for
production of ATP.
Starch is long chains of glucose
units. This polysaccharide is produced mostly by
green plants for energy storage.
Sucrose, table sugar, produced by
plants; it is the readily hydrolyzed disaccharide consisting of fructose and
glucose.
Glycation:
a process where a monosaccharide (simple sugar) randomly attaches to
proteins or lipid; this adversely affects their functions, thus glycation is a
major cause of our chronic age-related diseases.
Diabesity:
the
combination of diabetes and obesity that afflicts those on the Western diet—a
recently coined term.
Fat
(Free Fatty acids and triglycerides): up to 24 carbon molecules with an organic acid or glycerol
molecule on end.
Incretin: class of
hormones secreted by the stomach and intestines which causes insulin secretion
and produces satiety.
Insulin: a gateway
hormone is produced by the pancreas. Its
main function is to have cells absorb
glucose and store fat. Cells already
loaded with glucose, to prevent toxic level resist the message by insulin to
absorb more glucose. Insulin also regulates
other enzymes and hormones including leptin.
Low insulin is the cause of type 1 and 2 diabetes. Insulin also promotes
the storage in amino
acid, and thus we secret insulin by the incretin system in response to
proteins.
Insulin
resistance (IR): a condition of higher than normal amount of
blood insulin to lower blood glucose due to a diminished response to insulin by
various tissues. The pancreas then
releases even more insulin to lower blood glucose. IR is the condition which
causes the fat
accumulation in the liver and pancreas and obesity, and all their
comorbidities.
Ketogenic
diet (very
low carbohydrate diet): it
forces the body to rely upon just fats to
convert ADP to ATP to cause weight
loss
without restricting calories. It is named refers to the ketones produced in
this metabolic natural process.
Key Opinion Leaders (KOLs):
people who rise to top positions in their area of expertise. In fields
relevant to business some of these
people violate the standards of science to produce and spread
business-favorable spin, and are handsome rewarded for their services. The term
is used in that sense of bad
conduct. Pharma has used KOLs along with
regulatory capture to produce a drug disaster while selling it to medical
students, physicians, politicians, and the public as cutting edge science.
Leptin: produced by fat cells is in part
regulated by
insulin. Leptin in the brain suppresses
appetite and it also regulates metabolism.
Leptin is responsible for the 25% reduction in metabolism plus increased
appetite that eventually occurs during an energy-restricted diet. Leptin functions
to maintain fat storage and
to restore weight even years later.
Lipids
are a
group of naturally occurring fat like molecules including waxes, sterols, fats,
phospholipids, and others.
Metabolism in
reference to diet refers to the metabolic use of mainly either fat or
carbohydrate to convert ADP to the high
energy molecule ATP mostly by the mitochondria. During starvation proteins also can be used to make ATP.
NAFLD (Non-Alcoholic Fatty Liver
Disease): the accumulation of fat by liver cells
sufficient to significantly downgrade their various functions. The NHANES survey
2011 found NAFLD in 30% of adult population—similar % for Europe.
Type-2
diabetes (T2D): occurs
when the pancreas fails to produce enough insulin to lower glucose to its
normal range; it results from chronic IR
and the accumulation of fat in the pancreas which eventually causes the decline
in insulin.
[1]
Note: those who eat a very low sugar
diet, such as the traditional diet of the Japanese do not develop IR or NAFLD, and therefore have a very low--compared to those on the
Western diet—incidence of T2D, heart
attack and obesity (sugar is only 14 grams a day).
[2]
Artificial sweeteners have been shown to stimulate
the production of the signal the release
of insulin because of their taste.
[3]
Proteins in meats fish and poultry and an intermediate high insulin index
number though they don’t have carbs because of the incretin system—see Insulin
Index table at end. This is why calorie
restricted and very low carb diets for the long-term obese nearly always fail
because they don’t cleanse the liver.
This requires fast.